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Cadmium and Health Effects
2018-09-16 21:33:21 by George Detox News, Toxicity
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Though trace amounts of many metals are essential for the health of living things, there is no scientific evidence showing a nutritional role for cadmium.

Is cadmium harmful to humans or ecosystems?

Humans can be harmed by a single large exposure to cadmium, and by long-term exposure to higher-than-usual concentrations. Until the mid-1900s, cadmium had few industrial uses. People were rarely exposed to concentrated doses of cadmium and the metal was not recognized as a health concern. But as new uses for cadmium were found, and as the industrial processes that produce the metal increased worldwide, the toxic effects of cadmium began to surface.

Some of the earliest cases of cadmium poisoning were reported in Belgium in 1858 in workers who inhaled cadmium dust as a result of polishing silver with cadmium carbonate. This kind of exposure can cause severe respiratory distress, emphysema, and even death.

Public awareness of cadmium’s toxic effects rose with the post-World-War-II outbreak of the “Itai-Itai” Disease (“Ouch-Ouch” Disease) in Japan, which had been caused by a release of cadmium into the run-off water from the Kamioka mine. Farmers in the region used the run-off to irrigate rice patties and other crops. Cadmium quickly became concentrated in the crops, and before long local women began to experience pain in their bones and joints, which eventually became so excruciating that they were bed-ridden. The cadmium, it was later found, had interfered with calcium metabolism, leading to reduction in calcium content and the density and strength of their bones. Simple movements, in some cases, caused the weakened bones to break. Removing cadmium from industrial wastewater halted the incidence of this extremely painful type of chronic cadmium poisoning and no new cases have been recorded in Japan since. (Itai-itai occurred primarily in post-menopausal women who had several children and was probably related as well to vitamin D deficiencies, hormonal status and other factors.)

The toxicity of cadmium is attributed, in part, to its ability to accumulate in living things. Cadmium is rare in nature and consequently plants and animals have not evolved with efficient means of metabolizing large amounts of the metal. Small amounts of the metal are bound up by the protein metallothionein and are removed from the body, but since organisms are unable to isolate and remove large amounts efficiently, long-term exposure to high levels can result in accumulation in body tissues. Under these conditions, cadmium can remain in the body for years. Most of the metal accumulates in the bones, liver and kidneys, where it can damage the functioning of those organs.

Cadmium can also bioaccumulate in the ecosystem. Crops treated with cadmium-containing fertilizer or commercial sludge can accumulate above-normal cadmium concentrations and pass them on through the food web to higher organisms such as livestock and humans as in the case of the Kamioka mine in Japan.

Some organisms absorb cadmium better than others. Among plants, staple foods such as wheat, rice and potatoes have been shown to accumulate higher amounts of cadmium. The overall highest levels of cadmium in food can be expected in the livers and kidneys of animals and in shellfish such as oysters and clams.

How does cadmium harm living things?

Cadmium is known to accumulate in the kidneys, and some scientists believe that damage to kidney tissue may lead to kidney disease, high blood pressure and heart disease. Calcium related kidney damage leads to calcium deficiencies in the rest of the body, particularly in the skeleton. As the “Itai-Itai” syndrome made clear, in extreme cases cadmium can contribute to aching bones and joints, progressing to extreme deformities and brittleness of bones. Some humans with high blood pressure have been found to have abnormally high amounts of cadmium in their urine, and animals given cadmium in food or water developed kidney and liver disease, high blood pressure, iron-poor blood and nerve or brain damage. Fortunately there have been no reported cases of Itai-Itai since the 1960s.

Excessive cadmium exposure may weaken the body’s immune system, and it is also believed to be linked to lung cancer. Some studies suggest it causes prostate enlargement. Some scientists suspect that cadmium may be a reproductive toxin. Some studies have found that animals exposed to high levels of cadmium had a higher incidence of premature birth, low birth weight, stillbirth and spontaneous abortion. Animal studies also suggest that cadmium exposure is linked to behavioral problems and learning disabilities.

People whose diets are deficient in zinc, copper, iron, calcium and vitamin D may be at higher risk for health complications from cadmium. These elements, which look and behave in a way that is chemically similar to cadmium, can be replaced by cadmium when the essential elements are in short supply. Bodily proteins that capture and metabolize essential metals can also absorb cadmium particles due to its similar chemical behavior.
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Arsenic and our Health
2018-09-16 21:31:58 by George Detox News, Toxicity
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Studies in animal species provide strong evidence that arsenic is an essential trace element – at least for birds and mammals. When researchers completely eliminated arsenic from the diets of animals in experiments, the animals became ill; some developed reproductive problems. The offspring of these arsenic-deprived adults were born with developmental problems. Putting a small amount of arsenic back into the animals’ diets completely reversed these effects.

Dietary requirements for arsenic in humans are still controversial. There are trace amounts of arsenic in almost all food and water, air and soil, so it is difficult to find humans who are isolated from all sources of arsenic. There are no known human health effects of arsenic deficiency, if such exist, and the effects observed in arsenic-deficient animals would be hard to detect and characterize in humans. Most investigators believe that it is likely that we receive all the arsenic we need from a normal diet, and there is currently no recommendation for a daily dietary intake for humans.

Nutritionists and toxicologists find themselves on opposite sides of an interesting question when they consider the human health effects of elements such as arsenic. In many cases an element can be toxic at one dose and healthful, even essential for health, at another. If it were somehow possible to eliminate from the environment all traces of elements known to have toxic effects, would this have a negative effect on human health? Because arsenic is ubiquitous in the environment, this question is likely to remain moot.

How does arsenic harm living things?

Arsenic’s toxic effects largely depend on its chemical and physical form and how one is exposed. A large single dose that produces an immediate effect is called an acute exposure; a smaller amount over a long period of time that produces a gradual or delayed effect is called a chronic exposure.

At acute exposures, such as in accidental or intentional poisonings, arsenic can displace elements involved in the fundamental chemical processes of cells. For example, arsenic has an affinity for binding to sulfur. Certain enzymes involved in metabolism use the sulfur atom of a cysteine amino acid to carry out their function. If arsenic binds to the sulfur at these sites, the enzymes can begin to behave in abnormal ways or lose their ability to function. Arsenic, in the form of arsenate, can also resemble phosphate, which is used by cells for energy and signaling. By displacing phosphate in enzymes or signaling proteins, arsenic can block energy production and normal cell signaling.

At lower chronic exposures, such as in most environmental or occupational exposures, arsenic appears to indirectly modify the way cells communicate. Recent studies at Dartmouth suggest that arsenic may act as an endocrine disrupter by binding to hormone receptors, interfering with normal cell signaling of hormones through those receptors. Disruption of these endocrine receptors by arsenic in this way may contribute to the development of diabetes, cancer and vascular disease.

Other Dartmouth researchers have found that arsenic may interfere with molecular signals that prompt the cells lining heart and blood vessels to grow. The subsequent build-up of these cells can narrow the passage inside blood vessels, restricting the flow of blood. This may be one of the mechanisms that enable arsenic to contribute to cardiovascular disease and other blood vessel diseases.

Dartmouth researchers are also trying to understand other ways in which arsenic increases the risk of certain kinds of cancer. Unlike many other known chemical carcinogens, arsenic does not cause damage to DNA or cause mutations in genes. Instead, it appears to indirectly modify the way cells behave in ways that increase their probability of becoming cancer cells, perhaps in combination with other carcinogens such as cigarette smoke or other environmental contaminants.

What makes some forms of arsenic more harmful to humans?

The effect arsenic has on living things is strongly governed by its form or species. Although metals are simple elements, metal atoms can combine into different forms that vary in chemical and biological properties. Some forms of arsenic are highly toxic; others are essentially non-toxic. The reasons are rooted in basic chemistry.

Atoms are made up of a nucleus – a mixture of positively charged particles called protons and neutral particles called neutrons — around which negatively charged particles called electrons orbit. The positive, negative or neutral charge on an atom, called its “ionic state,” is governed by how many electrons it has circling around it balancing the positive charges of its protons. Atoms can gain or lose electrons to change their ionic charge, and the sharing of electrons is primarily how atoms bond together to form molecules.

The most common and stable forms of arsenic in nature are arsenite, also called or arsenic (+3), and arsenate, or arsenic (+5). Arsenic (+3) is arsenic with three fewer electrons than protons, giving it a plus three positive charge; arsenic (+5) is arsenic with five fewer electrons than protons, giving it a plus five positive charge. These two forms can be readily converted back and forth both in nature and inside our bodies depending on the local chemical environment – such as changes in acidity (pH), the presence of oxygen or iron, and what other molecules are present. Arsenite is believed to be slightly more toxic than arsenate, but since they are so easily inter-converted, both forms are considered a health risk.

Once arsenic (+3) or arsenic (+5) atoms combine with other elements to form molecules, the molecules acquire chemical and biological properties of their own. When arsenic binds to elements such as sulfur, oxygen, and chlorine it forms molecules known as inorganic compounds; when arsenic binds to molecules containing carbon it forms organic compounds. Inorganic forms of arsenic are, in general, more toxic to humans since they are less stable and may allow arsenic to interact with important cellular molecules.

Both the inorganic and organic forms of arsenic are readily eliminated from the body through the urine. When we are exposed to inorganic arsenic, the body routinely changes, or metabolizes, it into one or more organic forms by successively adding carbon atoms to it. Scientists once believed that this process – known as methylamine – was a natural arsenic detoxification process for both humans and other animals.

But new findings have challenged that idea. Animal species that do not methyl ate arsenic are not only able to excrete inorganic arsenic efficiently but appear to be no more sensitive to its toxic effects than animals that methyl ate. More recently, scientists have found that a simple ethylated form of arsenic called mono-methyl arsenic (III) can cause cancer in animals. On the other hand, fish and other animals contain a highly ethylated form of arsenic called arsenobetaine or “fish arsenic” which is essentially non-toxic and is readily eliminated by our bodies. So although fish may have high amounts of arsenic in them, it is primarily in a form that is not a health risk to humans.

There is evidence that humans and other animals can build up tolerance to the toxic effects of arsenic. A society of “arsenic eaters” who deliberately consumed arsenic-laden soils in their religious practices developed a high tolerance for arsenic. Rasputin was reported to regularly ingest arsenic to build tolerance and to protect him from poisoning.

What amount of arsenic is toxic to humans?

Like any other poison, whether an exposure to arsenic is harmful largely depends on its chemical and physical form and how one is exposed. Toxicologists use the terms dose, duration and route of exposure, meaning the amount of a substance taken in, the period of time the exposure lasts, and the way the substance enters the body. One way of being exposed to arsenic is by breathing it in as a dust. This primarily occurred in workplace settings where arsenic or products containing arsenic were used, and before new knowledge led to the development of modern worker safety measures. There is normally little or no uptake of arsenic through the skin at environmental levels, though it was of concern in previous workplace exposures (such as long-term use of arsenic-containing pesticides) or through use of arsenic-containing medications applied directly to the skin. The route of exposure of most concern today is ingesting arsenic, particularly through drinking water contaminated by inorganic arsenic.

The concentrations of arsenic found in the heavily contaminated drinking water of Bangladesh are between 170 and 1500 micrograms per liter (A microgram is a millionth of a gram). By contrast, a person would have to ingest more than 70,000 micrograms of arsenic all at once to be fatally poisoned by a single dose. Nevertheless, exposure over a long period of time to concentrations of arsenic such as those found in Bangladesh is associated with a wide range of illnesses.

Much of the world’s current safe drinking water standards for arsenic are based on risk estimates using data on people exposed to very high levels of arsenic through their occupations or through drinking water in areas such as Bangladesh, Taiwan and parts of South America. Few studies have examined the effects of lower doses on people over long periods of time.

Dartmouth researchers are conducting epidemiological studies to determine the health effects of drinking water containing arsenic at the elevated levels found in certain regions of the United States. These levels -typically between 50 and 200 micrograms per liter – are much lower than those of Bangladesh but are still considered high enough to be of concern

Can arsenic cause cancer?

Like many chemicals, arsenic’s effects on cancer at first appear paradoxical. On the one hand, arsenic is one of a handful of chemicals that is well established as a human carcinogen based on direct evidence in human populations. In fact, this was evident in humans long before there was evidence for arsenic’s cancer-causing effects in laboratory animals. On the other hand, arsenic has been shown to be effective as a cancer chemotherapy drug and can be used to induce complete cures in certain forms of cancer.

The evidence that arsenic is a carcinogen comes primarily from studies of disease in regions of Taiwan, South America, India, and Pakistan where drinking water contains elevated levels of arsenic. These studies have demonstrated a strong association between high levels of arsenic in drinking water and the risk of lung, skin, bladder and other cancers. Interestingly, these studies have suggested that arsenic is unique in being the only known agent that increases lung or skin cancer risk where ingestion is the only route of exposure.

Surprisingly, it has been difficult to demonstrate that arsenic can increase the incidence of cancer in animals despite the strong human epidemiological data. This is also true of several other carcinogenic metals including chromium, cadmium and nickel. The reasons are unclear, but one view is that these agents act indirectly, by increasing the risk of cancer from other factors. This would not be evident in experiments in which animals are raised in a relatively pristine laboratory environment and exposed only to the metal in question.

Beginning around the 1970s, the Chinese began to systematically experiment with the use of arsenic to treat certain cancers. Most of these studies were published in the Chinese medical literature, which did not become accessible to the western world until the late 1980s. In particular, the Chinese demonstrated that use of arsenite -inorganic arsenic trioxide – was highly effective in treating certain leukemia. Arsenite was particularly useful for people whose leukemia were resistant to chemotherapy treatment using retinoic acid, a derivative of vitamin A. The results of these arsenic studies were recently confirmed in a small U.S. cancer trial as well. These studies suggest that arsenic may prove to be an effective anti-cancer agent for other malignancies in the coming years.

Arsenic’s paradoxical behavior as both cause and treatment for cancer is an example of an often-repeated maxim attributed to Paracelsus, a physician and alchemist who lived 500 years ago: “the right dose differentiates a poison from a remedy.”

What are the symptoms of arsenic poisoning?

Arsenic has been the poison of choice since antiquity because it is difficult to detect in food and water and because the symptoms of poisoning by arsenic can be mistakenly attributed to many other ailments.

The effects of arsenic poisoning differ depending upon whether the exposure is acute – a large dose in a short period of time – or chronic – lower doses over an extended period of time.

At a very high, single dose arsenic can cause severe shock, general paralysis, delirium and then death within a few hours. At a somewhat lower dose the primary symptoms are nausea, headache, intense gastrointestinal pain, vomiting and diarrhea. This can be followed by extensive gastrointestinal bleeding, loss of blood pressure and a decrease in brain function followed by death. These effects are rare except in cases of intentional poisoning or suicides.

Workers and others who have been exposed to arsenic over long periods of time, principally by breathing it or ingesting it, can exhibit symptoms that include melanosis, a change in pigmentation of the skin similar to freckling; hyperkeratosis, an extensive thickening of the skin, especially the palms of the hands and soles of the feet; damage to heart and blood vessels; a decrease in both red and white blood cell production; and severe inflammation of the liver.

These symptoms are also seen in people who live in regions where drinking water contains between 100 and 1,500 parts per billion of arsenic.

Drinking-water arsenic at these levels is also associated with an increased risk of diabetes mellitis (type 2 or adult-onset diabetes), with damage to heart and blood vessels and, in some areas of the world, a condition called Blackfoot disease. This causes the feet or sometimes hands to lose circulation and to turn “black.” There is also a strong association between arsenic in drinking water and an increased risk of lung, skin, bladder and other cancers.

Arsenic is cleared from the body quickly, so the most important remedy for arsenic poisoning is eliminating exposure. The most serious effects of arsenic, such as cancer and diabetes, are believed to require long, continuous exposures perhaps lasting 20 years or more.

In cases of extreme poisoning, chemical compounds called chelating agents can be used as an antidote. Chelating agents such as “British anti-lewisite” (BAL) and other more modern therapies work by binding arsenic tightly in complexes, making it inactive. This can help remove arsenic from a person’s body, averting severe toxicity and death.
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Heavy Metal Sources and Effects
2018-09-16 21:28:05 by George Detox News, Toxicity
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ALUMINIUM – alum, aluminum foil, animal feed, antacids, aspirin, auto exhaust, baking powder, beer, bleached flour, cans, ceramics, cheese, cigarette filters, color additives, construction materials, cookware, cosmetics, dental amalgams, deodorants, drinking water, drying agents, dust, insulated wiring, medicinal compounds, milk products, nasal spray, pesticides, pollution, salt, tap water, tobacco smoke, toothpaste, treated water, vanilla powder.

EFFECTS: ALS, Alzheimer’s, anemia, appetite loss, behavioral problems, cavities, colds, colitis, confusion, constipation, dementia, dry mouth, dry skin, energy loss, excessive perspiration, flatulence, headaches, heartburn, hyperactivity, inhibition of enzyme systems, kidney dysfunction, lowered immune function, learning disabilities, leg twitching, liver dysfunction, memory loss, neuromuscular disorders, numbness, osteoporosis, paralysis, Parkinson’s disease, peptic ulcer, psychosis, reduced intestinal activity, senility, skin problems, spleen pain, stomach pain, weak and aching muscles

ARSENIC – burning of arsenate treated building materials, coal combustion, insect sprays, pesticides, soils (arsenic rich), seafood from coastal waters, especially mussels, oysters and shrimp

EFFECTS: abdominal pain, anorexia, brittle nails, diarrhea, nausea, vomiting, chronic anemia, burning in mouth / esophagus / stomach / bowel, confusion, convulsions, dermatitis, drowsiness, enzyme inhibition, garlicky odor to breath / stool, hair loss, headaches, hyper-pigmentation of nails and skin, increased risk of liver / lung / skin cancers, low grade fever, mucous in nose and throat, muscle aches / spasms / weakness, nervousness, respiratory tract infection, swallowing difficulty, sweet metallic taste, throat constriction

BERYLLIUM – coal burning, manufacturing, household products, industrial dust

EFFECTS: disturbance of calcium and vitamin D metabolism, magnesium depletion, lung cancer, lung infection, rickets, vital organ dysfunction

CADMIUM – airborne industrial contaminants, batteries, candy, ceramics, cigarette smoke, colas, congenital intoxication, copper refineries, copper alloys, dental alloys, drinking water, electroplating, fertilizers, food from contaminated soil, fungicides, incineration of tires / rubber / plastic, instant coffee, iron roofs, kidney, liver, marijuana, processed meat, evaporated milk, motor oil, oysters, paint, pesticides, galvanized pipes, processed foods, refined grains / flours cereals, rubber, rubber carpet backing, seafoods (cod, haddock, oyster, tuna), sewage, silver polish, smelters, soft water, solders (including in food cans), tobacco, vending machine soft drinks, tools, vapor lamps, water (city, softened, well), welding metal

EFFECTS: alcoholism, alopecia, anemia, arthritis (osteo and rheumatoid), bone disease, bone pain in middle of bones, cancer, cardiovascular disease, cavities, cerebral hemorrhage, cirrhosis, diabetes, digestive disturbances, emphysema, enlarged heart, flu-like symptoms, growth impairment, headaches, high cholesterol, hyperkinetic behavior, hypertension, hypoglycemia, impotence, inflammation, infertility, kidney disease, learning disorders, liver damage, lung disease, migraines, nerve cell damage, osteoporosis, prostate dysfunction, reproductive disorders, schizophrenia, stroke

COPPER – birth control pills, congenital intoxication, copper cookware, copper IUDs, copper pipes, dental alloys, fungicides, ice makers, industrial emissions, insecticides, swimming pools, water (city / well), welding, avocado, beer, bluefish, bone meal, chocolate, corn oil, crabs, gelatin, grains, lamb, liver, lobster, margarine, milk, mushrooms, nuts, organ meats, oysters, perch, seeds, shellfish, soybeans, tofu, wheat germ, yeast

EFFECTS: acne, adrenal insufficiency, allergies, alopecia, anemia, anorexia, anxiety, arthritis (osteo & rheumatoid), autism, cancer, chills, cystic fibrosis, depression, diabetes, digestive disorders, dry mouth, dysinsulinism, estrogen dominance, fatigue, fears, fractures, fungus, heart attack, high blood pressure, high cholesterol, Hodgkin’s disease, hyperactivity, hypertension, hyperthyroid, low hydrochloric acid, hypoglycemia, infections, inflammation, insomnia, iron loss, jaundice, kidney disorders, libido decreased, lymphoma, mental illness, migraines, mood swings, multiple sclerosis, myocardial infarction, nausea, nervousness, osteoporosis, pancreatic dysfunction, panic attacks, paranoia, phobias, PMS, schizophrenia, senility, sexual dysfunction, spacey feeling, stuttering, stroke, tooth decay, toxemia of pregnancy, urinary tract infections, yeast infections

IRON – drinking water, iron cookware, iron pipes, welding,. foods: blackstrap molasses, bone meal, bran, chives, clams, heart, kidney, leafy vegetables, legumes, liver, meat, molasses, nuts, organ meats, oysters, parsley, red wine, refined foods, shellfish, soybeans, wheat germ, whole grains

EFFECTS: amenorrhea, anger, rheumatoid arthritis, birth defects, bleeding gums, cancer, constipation, diabetes, dizziness, emotional problems, fatigue, headache, heart damage, heart failure, hepatitis, high blood pressure, hostility, hyperactivity, infections, insomnia, irritability, joint pain, liver disease, loss of weight, mental problems, metallic taste in mouth, myasthenia gravis, nausea, pancreas damage, Parkinson’s disease, premature aging, schizophrenia, scurvy, shortness of breath, stubborness

LEAD – ash, auto exhaust, battery manufacturing, bone meal, canned fruit and juice, car batteries, cigarette smoke, coal combustion, colored inks, congenital intoxication, cosmetics, eating utensils, electroplating, household dust, glass production, hair dyes, industrial emissions, lead pipes, lead-glazed earthenware pottery, liver, mascara, metal polish, milk, newsprint, organ meats, paint, pencils, pesticides, produce near roads, putty, rain water, pvc containers, refineries, smelters, snow, tin cans with lead solder sealing (such as juices, vegetables), tobacco, toothpaste, toys, water (city / well), wine

EFFECTS: abdominal pain, adrenal insufficiency, allergies, anemia, anorexia, anxiety, arthritis (rheumatoid and osteo), attention deficit disorder, autism, back pain, behavioral disorders, blindness, cardiovascular disease, cartilage destruction, coordination loss, concentration loss, constipation, convulsions, deafness, depression, dyslexia, emotional instability, encephalitis, epilepsy, fatigue, gout, hallucinations, headaches, hostility, hyperactivity, hypertension, hypothyroid, impotence, immune suppression, decreased IQ, indigestion, infertility, insomnia, irritability, joint pain, kidney disorders, learning disability, liver dysfunction, loss of will, memory loss (long term), menstrual problems, mood swings, muscle aches, muscle weakness, muscular dystrophy, multiple sclerosis, myelopathy (spinal cord pathology), nausea, nephritis, nightmares, numbness, Parkinson’s disease, peripheral neuropathies, psychosis, psychomotor dysfunction, pyorrhea, renal dysfunction, restlessness, retardation, schizophrenia, seizures, sterility, stillbirths, sudden infant death syndrome, tingling, tooth decay, vertigo, unintentional weight loss

MERCURY – adhesives, air conditioner filters, algaecides, antiseptics, battery manufacturing, body powders, broken thermometers, burning newspapers and building materials, calomel lotions, cereals, congenital intoxication, cosmetics, dental amalgams, diuretics, fabric softeners, felt, floor waxes, fungicides, germicides, grains, industrial waste, insecticides, laxatives, lumber, manufacture of paper and chlorine, medications, mercurochrome, paints, paper products, pesticides, photoengraving, polluted water, Preparation H, psoriasis ointment, seafoods (especially tuna and swordfish), sewage disposal, skin lightening creams, soft contact lens solution, suppositories, tanning leather, tattooing, water (contaminated), wood preservatives

EFFECTS: adrenal dysfunction, allergy, alopecia, anorexia, anxiety, birth defects, blushing, brain damage, cataracts, cerebral palsy, poor coordination / jerky movements, deafness, depression, dermatitis, discouragement, dizziness, drowsiness, eczema, emotional disturbances, excess saliva, fatigue, gum bleeding and soreness, headaches (band type), hearing loss, hyperactivity, hypothyroidism, forgetfulness, immune dysfunction, insomnia, irritability, joint pain, kidney damage, loss of self-control, memory loss, mental retardation, metallic taste, migraines, nervousness, nerve fiber degeneration, numbness, pain in limbs, rashes, retinitis, schizophrenia, shyness, speech disorders, suicidal tendencies, tingling, tremors (eyelids, lips, tongue, fingers, extremities), vision loss, weakness

NICKEL – butter, fertilizers, food processing, fuel oil combustion, hydrogenated fats and oils, imitation whipped cream, industrial waste, kelp, margarine, nuclear device testing, oysters, stainless steel cookware, tea, tobacco smoke, unrefined grains and cereals, vegetable shortening

EFFECTS: anorexia, kidney dysfunction, apathy, disruption of hormone and lipid metabolism, fever, hemorrhages, headache, heart attack, intestinal cancer, low blood pressure, muscle tremors, nausea, oral cancer, skin problems, vomiting
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Sources of Heavy Metals
2018-09-16 21:20:18 by George Detox News, Toxicity
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In the previous email that you received a few days ago entitled “Heavy metals and Health” I talked a little about what heavy metals were and how prevalent they are in today’s society. Perhaps you have been asking yourselves, “where do all these heavy metals come from,” given that they are everywhere around us, even up in the North and South poles?

Remember that we mentioned that heavy metals have been implicated in various research studies to cause as many as 20% of learning disabilities, 20% of all strokes and heart attacks, and in certain areas to be a factor in over 40% of all birth defects – these are really nasty metals!

Sources of Toxic Metals
A source of toxic lead is from paint chips, drinking water, fertilizer, food, auto and industrial emissions, and dust. Cadmium is found in regions with high emissions from incinerators, coal plants, or cars, as well as in shellfish and cigarette smoke. Other common sources include rural drinking water wells, processed food, fertilizer, and old paint. Aluminium is found in aluminium cookware, antiperspirants, cheese and other processed food. Nickel, which is highly toxic, is commonly seen in dental crowns and braces, along with jewellery, etc. (Nickel and inorganic mercury frequently produce allergic type autoimmune reactions and associated problems). Manganese and other metal exposure can come through welding or metal work.

Mercury is another major issue – the most common significant exposure for most people is to mercury vapour from amalgam fillings. Dental amalgams usually emit 1-10 ug/day; the amount of mercury found in the brain is strongly correlated with the number of dental fillings. Researchers have shown that chewing gum can double the mercury levels in the blood and triple the levels in urine for those that have amalgam fillings.

Seafood contaminated with mercury is another issue of concern – generally larger fish have most mercury, due to bioaccumulation in the food chain. The HIGHEST levels of mercury have been found in the following fish, with mean mercury levels in parts per million (ppm);

Tilefish (Golden bass or Golden snapper), 1.45; Swordfish, 1.00; Shark, 0.96; King Mackerel, 0.73 and Grouper (Mycteroperca) 0.43.

LOWER levels have been found in the following fish:

Tuna (fresh or frozen) 0.32; Lobster Northern (American) 0.31; Halibut 0.23; Tuna (canned) 0.17; Crab Blue 0.17; Scallop 0.05; Catfish 0.07; Salmon ND; Oysters ND; Shrimp ND (ND = not detectable).

During the spring of 2001 the State Department of Health (DOH) issued a fish-consumption advisory for women of childbearing age and children under age six, due to high levels of mercury in certain breeds of carnivorous fish such as shark, swordfish, tilefish, king mackerel, and tuna.

Another major exposure source to infants is from thimerosal, a water-soluble, cream-colored crystalline powder used as a preservative in vaccines that contain 49.6% mercury by weight. It is present in over 30 licensed vaccines in the US, in concentrations of 0.003% to 0.01%. In the human body, thimerosal is metabolized to ethylmercury and thiosalicylate which are highly toxic substances.

The EPA safe limit for mercury exposure is one-tenth of a microgram (0.1 mcg/kg) but it is common for most children to be vaccinated on the day of birth with the hepatitis B vaccine which contains 12 mcg of mercury (30 times the safe level). At 4 months, they are again vaccinated with the DtaP and HiB vaccine on the same day, which provides a further 50 mcg of mercury (60 times the safe level). At 6 months they receive the Hep B, Polio with a further 62.5 mcg of mercury (78 times the safe level). These figures are calculated for an infant’s average weight in kilograms for each age. By age two, American children have received 237 micrograms of mercury through vaccines alone, which is thousands of times more than the EPA safe limit.

Mercury in the thimerosal preservative in vaccines is 50 times more toxic than liquid mercury because injected mercury is far more toxic than ingested mercury and converts to ethylmercury, which has a natural affinity for brain cells and nerves. The fact that babies do not have a blood-brain barrier makes penetration easier. Moreover, infants have difficulty excreting mercury, as they do not produce bile, which is required for proper excretion. If the nurse giving the injection did not shake the vial according to directions before drawing out the vaccine dose, there is a chance that the child receiving the last dose could get as much as 10 times the usual amount of mercury in one dose.

So you see, toxic metals are literally everywhere – in our food, our water, the air we breathe as well as the medications we take thinking that these are good for our health. The question that requires answering is how do we protect ourselves and our loved ones from these toxic metals, and what health problems do they really cause?

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Fish: Do I Eat, Do I Not Eat
2018-09-16 21:16:20 by George Detox News, Toxicity
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What’s so healthy about eating fish?

Fish is a high-protein, low-fat food that provides a range of health benefits. White-fleshed fish, in particular, is lower in fat than any other source of animal protein, and oilier fish contain substantial quantities of omega-3s, or the “good” fats in the human diet. In addition, fish does not contain the “bad” fats commonly found in red meat – called omega-6 fatty acids.

Are fish contaminated?

Despite their valuable qualities, fish can pose considerable health risks when contaminated with substances such as metals (e.g., mercury and lead), industrial chemicals (e.g., PCBs) and pesticides (e.g., DDT and dieldrin). Through increased testing, many of our oceans, lakes and rivers are now known to be surprisingly tainted. As a result, some fish are sufficiently contaminated that Environmental Defence recommends limited or no consumption.

Where do contaminants come from?

Contaminants enter the water in a variety of ways. Industrial and municipal discharges, agricultural practices, and storm water runoff can all deposit harmful substances directly into the water. Rain can also wash chemicals from the land or air into streams and rivers. These contaminants are then carried downstream into lakes, reservoirs and estuaries.

Fish take in these substances in several ways, and their contaminant levels depend on factors like species, size, age and location. Mercury, for example, is naturally converted by bacteria into methylmercury. Fish absorb methylmercury mostly from their food, but also from the water as it passes over their gills. Generally, larger and older fish have had more time to bioaccumulate mercury from their food and the water than smaller and younger fish. In addition, large predatory fish (like sharks and swordfish) near the top of marine food chains are more likely to have high levels of mercury than fish lower in marine food chains due to the process of biomagnification.

Fish can also absorb organic chemicals (such as PCBs, dioxins and DDT) from the water, suspended sediments, and their food. In contaminated areas, bottom-dwelling fish are especially likely to have high levels of such toxins because these substances run off the land and settle to the bottom. These organic chemicals then concentrate in the skin, organs and other fatty tissues of fish. Wild striped bass, bluefish, American eel, and seatrout tend to be high in PCBs, since they are bottom-tending fish often found in contaminated rivers and estuaries.

What are the risks of eating seafood contaminated with industrial pollutants?

Contaminants such as mercury, PCBs and dioxins build up in your body over time. Health problems that may result from eating contaminated fish range from small, hard-to-detect changes to birth defects and cancer. It can take 5 years or more for women in their childbearing years to rid their bodies of PCBs, and 12-18 months to significantly reduce their body burden of mercury. Mothers who eat contaminated fish before becoming pregnant may have children who are slower to develop and learn. Developing fetuses are exposed to stored toxins through the placenta. Women beyond their childbearing years and men face fewer health risks from contaminants than children do. Following the advice below will minimize your exposure and reduce the health risks associated with these contaminants.

What about mercury in canned tuna?

The two most popular types of canned tuna – white and light – vary greatly in their average mercury content. Canned white tuna consists of albacore, a large species of tuna that accumulates moderate amounts of mercury. Consequently, Environmental Defence recommends that adults and children limit their consumption of canned white tuna.

Canned light tuna usually consists of skipjack, a smaller species with approximately one-third the mercury levels of albacore. Therefore, Environmental Defence only recommends that young children (ages 0-6) limit their consumption of canned light tuna. However, recent news reports suggest that some canned light tuna actually contains yellow fin tuna, a species that is similar in size and mercury content to albacore. These products are sometimes (but not always) labelled ‘gourmet’ or ‘tonno’, and their consumption should be limited by adults and children. Overall, it’s best to exercise caution in how much tuna you (or especially your children) consume.

Do the health benefits of omega-3s outweigh the risks associated with contaminants in seafood?

There is no definitive answer to this question, but the information provided here can help you decide for yourself. For young children and women of childbearing age, consumption of mercury-contaminated fish can severely impact a child’s development. However, other sub-populations (older women and men) may find it an acceptable trade-off to exceed recommended seafood meal limits to increase their omega-3 intake. For our advisories concerning PCBs, dioxins and pesticides, the cancer risk (1 in 100,000 – the level recommended by the EPA) may not outweigh the benefits of omega-3s for people at high risk of cardiovascular disease. However, these chemicals are known to cause serious health problems besides cancer, so the trade-offs are not simple.

What about natural toxins in seafood?

Besides industrial pollutants and other human-made contaminants, some seafood may also contain natural toxins if fish eat harmful algae or bacteria. In warm tropical waters, a toxin called ciguatera can work its way up the food chain and be present in toxic levels in large, predatory fish. Cooking does not destroy the toxin, and consumption of ciguatoxic fish can cause intense flu like symptoms.

In addition, fish like tuna, mackerel, bluefish and mahimahi begin decomposing soon after capture. If not stored properly, they may develop histamine called scombrotoxin. Eating fish (even cooked fish) with high concentrations of scombrotoxin can cause an allergy-like reaction, which is treatable with an antihistamine.

Uncooked shellfish may contain disease-causing bacteria, viruses or parasites. Raw oysters, clams and other shellfish pose a particular risk since they are filter feeders – straining tiny particles from the seawater for food. If the seawater contains disease-causing microorganisms, these accumulate in the shellfish. The Norwalk virus, which causes intestinal illness in humans, is often associated with eating raw oysters and clams. For this reason, it is important to get raw shellfish from a reliable source, or ensure that your shellfish is cooked thoroughly.

How can I reduce the risks?

Fish consumption is the primary route of exposure to contaminants like mercury and PCBs. Since these substances can damage developing nervous systems and impair learning, seafood contamination is a particular concern for young children and women of childbearing age. The best ways to reduce exposure are:
- Reduce consumption of fish known to be high in contaminants.
- Prepare your fish in a way that cuts down on toxins.
- Eat sport fish from a variety of water bodies, and try not to eat the same species of fish more than once a week.
How can I cook fish to reduce toxins?

Unfortunately, there are no cooking methods that will reduce mercury levels in seafood since it binds to proteins in fish tissue (including muscle). However, levels of PCBs, dioxins and some pesticides can be reduced by the following cooking methods, since these chemicals build up in fatty tissue.

Before cooking, remove the skin, fat (found along the back, sides and belly), internal organs, tomalley of lobster and the mustard of crabs, where toxins are likely to accumulate. This will greatly reduce the risk of exposure to a number of hazardous chemicals.

When cooking, be sure to let the fat drain away, and avoid or reduce fish drippings.

Serve less fried fish. Frying seals in chemical pollutants that might be in the fish’s fat, while grilling, broiling or poaching allows fat to drain away.

For smoked fish, it is best to fillet the fish and remove the skin before the fish is smoked.

How can I avoid getting sick from eating seafood?

Check fish carefully before buying. Bruises, brown spots and cloudy eyes all indicate decomposition, and possibly bacteria. Buy fish that was frozen or refrigerated immediately after capture.

Cook fish and shellfish thoroughly. Handle raw fish as you would handle other raw meat products. Take care not to cross-contaminate cooked food or vegetables with the utensils used to prepare raw fish, and wash utensils and hands thoroughly in-between handling.

Avoid shellfish from untraceable sources, particularly if eaten raw.

What fish should I avoid?

Low-contaminant fish are an important part of a healthy diet, and Environmental Defense encourages people to include such fish in their diets, especially if they are caught or farmed in an environmentally responsible manner. However, there are certain species that people (especially women of childbearing age and children) should eat in moderation or avoid altogether.

What can I do to protect myself and my family?

You will need to detoxify these heavy metals and other contaminants using a heavy metal chelator, but a natural one that has been tried and tested during scientific trials called HMD.
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What are Heavy Metals

2018-09-16 21:08:07 by George Detox News, Toxicity

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Heavy metals have nothing to do with Rock and Roll music or bands – they are non-essential toxic metals that damage your health. Examples of these include aluminium, arsenic, antimony, cadmium, lead, mercury, nickel, thallium, uranium, polonium and others.

Heavy metals are associated with many health problems – one of the main ways that they cause problems is by producing free radicals – nasty molecules in the body that damage cells, tissues and organs, as well as provoking the cell to mutate, possibly into cancer cells.

Toxic metals are everywhere – in vaccinations we find mercury, aluminium in the water supply, cadmium in cigarettes, mercury in amalgams and fish, arsenic in chickens used as animal growth promoters, as well as pesticides, lead in the atmosphere and even radioactive metals such as polonium-210, thallium and uranium being found on airplanes sitting on Heathrow’s runways!

AM I TOXIC?

The answer to this question is a categorical “yes!” It is an irrefutable fact that we live in a toxic soup of over 100,000 toxic chemicals and heavy metals. These are found all over the planet right up to the North and South Poles. Even Inuit Eskimo newborns in the North Pole have been found to have mercury, lead and pesticide residues in their blood, with American newborns having an average of 287 toxins in their blood, so what are the chances of an adult being squeaky clean? None!

Even though we do not get large amounts every time we consume water, food, chew with amalgams and breathe in from the atmosphere – these metals do accumulate in the body over time and can reach very toxic levels that can lead to degenerative diseases.

If you have amalgams in your mouth, the World Health Organization says that you could be absorbing a hugely toxic dose of up to 120 micrograms of mercury daily. Mother’s breastfeeding their children are inadvertently giving them large doses of this toxic mercury. Most drinking water contains aluminium; fish contains mercury; chickens could contain arsenic and travellers beware of radioactive metals. Yes, we live in this toxic soup so the question is not ARE we toxic but just HOW toxic we are!

HOW DO HEAVY METALS AFFECT ME?

Well, there are the common symptoms ranging from unexplained irritability, frequent periods of depression, skin irritation and itching, unexplained fatigue, bloating, memory problems and constipation through to chronic diseases such as heart disorders, arthritis, migraines, IBS and even chronic weight issues by disrupting your hormonal system.

Check out a list of the most common symptoms that are found in people that are known to be toxic in heavy metals and check out your own levels of toxicity by taking the HOW TOXIC AM I TEST? Online NOW! – (link this to the test questions that determine toxicity).

Symptoms of Heavy Metal Toxicity

Unexplained irritability
Constant or very frequent periods of depression
Numbness and tingling in the extremities
Frequent urination during the night
Unexplained chronic fatigue
Cold hands/feet even in warm weather
Bloating feeling most of the time
Difficulty remembering or use of memory
Sudden unexplained/unsolicited anger and advice
Constipation on a regular basis
Difficulty in even making simple decisions
Tremors or shakes of head, hands or feet, etc.
Twitching of face and other muscles
Experience frequent leg cramps
Constant or frequent ringing or noise in the ears
Get out of breath easily
Frequent or recurring heartburn
Excessive itching
Unexplained rashes, skin irritation
Constant/frequent metallic taste in the mouth
Jumpy, jittery, nervous
Constant death wish or suicidal intent
Frequent insomnia
Unexplained chest pains
Constant or frequent pain in the joints
Tachycardia
Unexplained fluid retention
Burning sensation on the tongue
Get headaches just after eating.
Frequent diarrhoea

THE HMD™ SOLUTION!

Most health conscious people will be detoxifying on a regular basis – part of this programme will also include a heavy metal detox too. It is best to use a gentle heavy metal detox such as HMD™ (Heavy Metal Detox) which is a natural dietary supplement that is available without prescription and can be taken by all age groups without side effects.

HMD™ has been scientifically tested with 350 people in a double blind, placebo controlled trial and has been shown to be effective at removing many different kinds of heavy metals without side-effects. It will also not remove the essential or good minerals from the body, as many other pharmaceutical chelators tend to do.

It is also affordable – the daily dose would cost you less than the price of an average chocolate bar and cheaper than a cup of coffee. It can also be taken by all the family, including children for eliminating heavy metals, or simply as a preventative measure as you would take your daily multivitamin and antioxidant.

Best effects will be obtained if you take it for 3-6 months. Many children are using it for autism and learning difficulties which the Centre for Disease Control in the US say that heavy metals are responsible for over 20% of learning difficulties in children. As one mother puts it:

“Alex is doing beautifully on the HMD™. I have been able to raise the dose. His speech is more frequent and clearer. His teacher reports “great” days at school. He is pretty regular and seems to actually be stimulated to move his bowels after his daily dose of HMD™ most times. There are other changes such as: singing with me, just knowing the words all of a sudden to songs, understanding us better, hearing better, etc.”

Other testimonials from using HMD™ include:

“Your work is brilliant and put my mind at ease about most of what is on the market that I’ve been thinking about trying next. I know I haven’t been wrong to take my son off all the other products we tried at the first sign of autoimmune response. The other products were not “whole” and were very, very hard on him”.

“A nurse practitioner in private practice and very experienced with detox has reported that the HMD™ is very gentle. She usually gets terrible cracks in her tongue when she detoxes and does not have any with the HMD™. Our Doctor of Oriental Medicine has seen urine tests from one family who trialed zeolite, NDF, and HMD™. The NDF and HMD™ pulled three times the heavy metals than zeolite, and the HMD™ was much more tolerable and gentle than the NDF. Clay baths and a form of metabolic NAET were used to support the chelators in all instances, a crucial step for detoxing children with autism as their excretion power is much diminished by the time they get help”.

“Oh, the gains are wonderful for us as a family on this HMD™! We are having to change how we act with Alex, he is so much more into us now and wants to do so much more with us. We were used to just ignoring him when we did certain things because he was just not as plugged in to the family routines”.
“We are having great results without detox stimming, etc., on HMD™. It’s very cheap, gentle, and effective. I will be posting our son’s hair/urine/fecal tests and mercury is showing on urine/fecal for the first time in four years. We are only about 1/4 through the first $59 bottle. Also we are all of a sudden seeing URANIUM big time in my son’s fecal test! My network of doctors/parents/etc. is also seeing a sudden rise in uranium in testing. I think you know what that means for us all ….”

THE HMD™ BENEFITS?

I am certain that you are more aware of the dangers of heavy metals now. These insidious, nasty metals are everywhere and we must get them out of our systems before they do damage. It is almost certain that everyone, even young babies have heavy metals in their body, so the best thing to do is take a natural heavy metal chelator that eliminates toxic metals from the body. This can be taken preventatively by all the family on a daily basis, much like you take a multivitamin or antioxidant.

HMD™ is one of the only scientifically researched natural chelators that can protect you from heavy metals, without side effects – it is safe for all age groups. So why not add this wonderful natural chelator to your daily intake of nutritional supplements and see the difference in energy, gut function, anti-aging, clearer mind, better memory and I.Q., less irritable, less skin problems and a whole lot more health benefits.

Also see the following benefits as heavy metals are gradually reduced in your body:

ELIMINATE unexplained irritability

ELIMINATE constant or very frequent periods of depression

ELIMINATE numbness and tingling in the extremities

ELIMINATE frequent urination during the night

ELIMINATE unexplained chronic fatigue

ELIMINATE cold hands/feet even in warm weather

ELIMINATE bloating feeling most of the time

ELIMINATE difficulty remembering or memory problems

ELIMINATE sudden unexplained/unsolicited anger and advice

ELIMINATE constipation

ELIMINATE difficulties in even making simple decisions

ELIMINATE tremors or shakes of head, hands or feet, etc.

ELIMINATE twitching of face and other muscles

ELIMINATE frequent leg cramps

ELIMINATE constant or frequent ringing or noise in the ears

ELIMINATE getting out of breath easily

ELIMINATE frequent or recurring heartburn

ELIMINATE excessive itching

ELIMINATE unexplained rashes, skin irritation

ELIMINATE constant/frequent metallic taste in the mouth

ELIMINATE being jumpy, jittery, nervous

ELIMINATE constant death wish or suicidal intent

ELIMINATE frequent insomnia

ELIMINATE unexplained chest pains

ELIMINATE constant or frequent pain in the joints

ELIMINATE tachycardia

ELIMINATE unexplained fluid retention

ELIMINATE burning sensation on the tongue

ELIMINATE Getting headaches just after eating.

ELIMINATE frequent diarrhoea

This data was taken from the Toxic Element research Foundation, Colorado Springs, Colorado. The database was composed of 1,320 patients who had completed the most current questionnaire format used by the Huggins Diagnostic Center for patients that were seeking treatment for heavy metal toxicity

Poisoning our Children
2018-09-16 19:30:23 by George Detox News, Toxicity
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The World Wildlife Fund’s (WWF) biomonitoring survey in 2003 demonstrated that irrespective of where we live or what we do, we are all contaminated with a cocktail of toxic man-made chemicals. Some of these chemicals can adversely affect the brain and the peripheral nervous system. The most well-known are the ubiquitous pollutants, now banned, such as PCBs and DDT. Unfortunately, the chemical industry does not seem to have learned its lesson: there are many other man-made chemicals still being produced and used today in everyday products in the home and workplace.

A report from the World Health Organization concludes:

“Exposure (particularly prenatal exposure) to certain endocrine disrupting chemicals (e.g. PCBs) can have adverse effects on neurological development… and behaviour – delays in.cognitive development have been found to be associated with neonatal PCB exposure..”

Data suggests that these may cause learning and behavioural difficulties. In humans, the brain and nervous system are very vulnerable because development takes place over a long period. It begins early in the womb and continues through puberty. The developing brain is uniquely sensitive, and effects on brain function and coordination can occur in children at levels that would not cause permanent effects in an adult.

Unless we take action now, it may be that our children won’t be as intelligent as they might be because of man-made chemicals. Worse still, they may develop behavioural problems. Our children are our future and our future is under threat.

Sources of toxins

Most of these toxins that can affect the intelligence and behaviour of our children occur in many, sometimes surprisingly familiar places:
- INCINERATORS, POWER STATIONS AND FACTORIES – all sources of dioxins and furans.
- OLD TRANSFORMERS, PAINTS AND FRIDGES – until the 1970s, a lot of electrical components that we had in our houses contained chemicals called
polychlorinated biphenyls (PCBs). These PCB’s have been found in fish and fish oils, meat and animal fats, and milk and dairy produce.
- COMPUTERS, TVs, FURNITURE, CARS AND VIDEOS – can all contain brominated flame retardant chemicals used to prevent fire starting or rapidly spreading.
- BOTTLES, CAN LININGS AND FILLINGS – many tin can linings, clear plastic re-usable water containers, baby feeding bottles and white dental fillings contain another hazardous chemical called bisphenol A (BPA). Of particular concern is the leaching from baby feeding bottles that can lead to direct exposure of very young infants. BPA also leaches into food contained in tins lined with an epoxy-resin coating.
Serious Impact on Our Children

Man-made chemicals are affecting our children’s intelligence and behaviour, compromising their ability to make sense of the world and affecting their movement skills. What are some of these specific mental health effects on our children?

EFFECT ON INTELLIGENCE AND MOTOR SKILLS

Effects on brain development associated with PCBs first came to light about 20 years ago when scientists began to see impacts on children born near Lake Michigan in North America. These children had been affected not by anything they had done, but by what their mothers had done. Their mothers had eaten fish contaminated by PCBs and this had affected the brain development of their children.

Visual Recognition and PCBs

Effects on visual recognition were seen in babies exposed to higher levels of PCBs in the womb and later tests showed that at four years of age these children did less well in short-term verbal memory tests predictive of learning ability. Studies elsewhere in the Great Lakes region backed up this data and found that PCBs were affecting children’s mental development and intelligence. When the children from around Lake Michigan were re-examined at age 11, those with higher exposure to PCBs were three times as likely to have low average IQ scores and twice as likely to be at least two years behind in reading comprehension.

Thyroid Disruption and PBDE’s

The increasing levels of these chemicals found in humans and wildlife underline the concerns regarding the reported effects on brain function and thyroid hormone action. Studies in Sweden showed that the sum of PBDE concentrations in breast milk increased 57-fold between 1972 and 1997 from 0.07 ng/g to 4.0 ng/g lipid, such that every five years the levels doubled. Levels have since declined in Sweden, but reports of work carried out at Lancaster University in the UK suggest much higher levels may be found in UK breast milk, with levels ranging from less than 1 ng/g to 69 ng/g lipid, with more than half the women having levels of 6ng/g or more.

Many pesticides have also been associated with effects on brain function and with thyroid disruption. The pesticides which are particularly under the spotlight with regard to neurotoxic effects include the organophosphates, DDT, pyrethroids and paraquat. A study in Mexico has shown startling effects in children believed to be exposed to high levels of pesticides in an area with intensive agriculture. A range of symptoms was seen, including poor hand and eye coordination, diminished memory, decreased physical stamina and decreased ability to draw a person, which is used as non-verbal measure of cognitive ability.

ALTERED MASCULINE AND FEMININE BEHAVIOUR

I was recently interviewed by a journalist here in Cyprus and towards the end of the interview she casually commented that there was a shortage of “real men” as they all seem to be feminized! It’s interesting that I have heard this comment on a number of occasions, but also for the shortage of femininity in women.

In addition to compromising children’s ability to process information, chemicals may be affecting the developing nervous system in other ways. As well as affecting intelligence, it seems that dioxins and PCBs are also tampering with the male and female behaviour patterns of children. Such effects might be due to the ability of PCBs and dioxins to disrupt the sex hormones, as both these chemicals are known to have sex hormone-disrupting properties.

Masculine and Feminine Play

The sex hormones not only influence reproduction, but also non-reproductive behaviour that shows sex differences. In Europe, researchers studying Dutch children exposed to background levels of pollution found that the effects of prenatal exposure to PCBs were different for boys and girls. In boys, higher prenatal PCB levels were related to less masculinized play, whereas in girls, higher exposure was linked with more masculinized play. On the other hand, higher prenatal dioxin exposure was associated with more feminized play in boys as well as girls. While this work is controversial, these effects are alarming and warrant more research to verify and understand the full implications.

BPA is also known to have oestrogen (female sex hormone) mimicking properties, and as such is a hormone-disrupting chemical. In addition to effects on the uterus in animals, it is reported to cause reduced nursing behaviour, more masculinized play behaviour in females and increased aggression in males, and to abolish the sex differences in open-field behaviour.

ATTENTION DEFICIT HYPERACTIVITY DISORDER

Scientists now suspect that man-made chemicals may be contributing to a range of learning disabilities, including attention deficit hyperactivity disorder (ADHD). ADHD manifests itself as several symptoms including problems with paying attention and difficulty in controlling impulsive behaviour. It has been suggested that although many factors are liable to be implicated in causing ADHD, neurotoxic chemicals may also contribute to its incidence.

This is particularly worrying because the disorder known as ADHD is estimated to affect around one in 20 children in the US, and in a significant number of individuals, some symptoms may persist into adolescence and adulthood. In Britain, prescriptions of the drug Ritalin, used to treat ADHD, increased markedly during the latter part of the 1990s.

The European Commission has registered its concern, and has warned that:

“the occurrence of developmental disabilities, such as learning disabilities, intellectual retardation and attention deficit hyperactivity disorder is certainly large enough to constitute a significant public health problem.”

Some studies suggest the involvement of chemicals. For example, response inhibition is frequently impaired in children with ADHD, and studies have shown a dose-dependent

association between PCB levels in children and an inability to prevent inappropriate behavioural responses which might be a predictor for ADHD. Brain (MRI) scans showed that children with sup-optimal development of certain areas of the brain seemed more vulnerable to the effects of PCBs. The smaller the splenium, (the back part of the bundle of fibres joining the two brain hemispheres) the larger the association between PCBs and response inhibition.

Indeed, measurable effects on the brain seem to occur with ADHD and patients with ADHD have been found to have smaller brain volumes than normal children. This gives weight to the suggestion that ADHD is a real, biologically-based phenomenon, and not just a disorder conjured up by .neurotic parents.

AUTISM

There is a concern that autism may be partly linked to chemical exposures, and that this developmental disorder has increased in recent years. Autism, a brain condition that is evident prior to three years of age, affects a person’s ability to form relationships and to behave normally in everyday life. There are no medical tests to determine whether a person has autism and diagnoses are based on observed behaviour. Autism is the term often used for the more severe cases, whereas the term autism spectrum disorders (ASD) includes milder forms of autism such as Asperger’s.

Studies of identical twins confirm a genetic component, and there is certainly a predisposition to autism condition in some families. Recent findings point to the possibility that the disorder spectrum is caused by a gene-environment interaction. Thus, it may be that to produce autism, it is necessary to have both susceptible genes, as well as some environmental (e.g. chemical) assault on these genes. Many chemicals have been mentioned as possibly playing a role. These include metals, some organochlorine and organobromine compounds, and some pharmaceuticals.

One suggestion is that chemicals might cause damage around the time of neural tube closure in the womb, perhaps by disrupting retinoids. Other researchers consider that differences in metabolism may be important. Mercury has been the focus of much concern, both with regard to infant exposure, due to its use as a preservative in vaccinations, and with regard to exposure in the womb, largely due to mothers eating fish contaminated with mercury, and particularly because it seems that mercury levels in the umbilical cord of newborns are higher than in their mother’s blood.

The increase in the frequency of the disorder certainly supports the suggestion of an environmental component. It seems that genetics loads the gun, but the environment pulls the trigger. Many studies have suggested that rates have risen over the years, although some reviewers caution that increased recognition of the disorder, coupled with other factors, may account for some of the increase. Nevertheless, it does appear that autism spectrum disorders are more prevalent than previously thought, and may be found in around six children per 1,000 or one in 166 children. The National Autistic Society suggests it may be nearer one in 110 children and points out that two thirds of teachers surveyed in England and Wales felt there were now more children with autism spectrum disorders than just five years ago. Translated nationally, around half a million people may suffer from autism spectrum disorders. The rates of autism itself are lower and estimated to be 16.8 per 10,000, or one in 600 children.

SAVE OUR CHILDREN

The accumulating research over the past decade or so is clearly showing that hazardous industrial chemicals dramatically affect our quality of life. We really should be fighting for our children’s rights were we can buy them toys, food and water that are safe and harmless.

In the past, many persistent and bioaccumulative chemicals, such as DDT and PCBs, have been banned too late to prevent damage. Now there is an ever more urgent need for action.

Many more persistent and bioaccumulative chemicals, which take a very long time to break down in the environment and build up in living things, are in use today. Such chemicals should be phased out, irrespective of their currently known toxicity, because it is almost impossible to predict and test for the long-term effects of low-level exposures that may take years to appear in humans and other long-lived animals. If we get it wrong, it is our children who will pay the price.

The EU is negotiating new chemical legislation to regulate industrial chemicals. This is a once in a generation opportunity to create a safer future for our children and wildlife. The World Wildlife Fund is calling for the legislation to:
- phase out chemicals that are persistent and bioaccumulative;
- phase out endocrine-disrupting chemicals;
- substitute these chemicals with safer alternatives and allow their continued use only where there is an overwhelming societal need, where no safer alternatives exist, and where measures to minimize exposure are put in place.
While the legislatures are battling this out, there are also many things that we can do directly to protect our children. We can begin buying more certified organic food which is far less toxic than food that is sprayed or fed with chemicals. We can also stop buying foods loaded with chemicals, E-factors, preservatives and colourings.

We can also help our children, and ourselves to eliminate these chemicals from our bodies. There are now natural chelators that have been tried and tested that can be used on a regular basis with no harmful effects – see www.detoxmetals.com

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Mercury – Multipotent cytotoxins
2018-09-16 19:26:57 by George Detox News, Toxicity
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Mercury is a multipotent cytotoxin that intervenes in the primary processes of the cell by bonding strongly with sulfhydryl and selenohydryl groups on albumen molecules in cell membranes, receptors and intracellular signal links, and by modifying the tertiary structure. The structure of albumen molecules is genetically determined, and this leaves ample scope for genetic polymorphism to manifest itself in varying sensitivity and types of reaction to mercury exposure. Mercury is toxic because it induces production of free oxygen radicals and modifies the redox potential of the cell.

Toxicity caused by excessive mercury exposure is now becoming recognized as a widespread environmental problem and is continuing to attract a great deal of public attention. A National Academy of Sciences study published in July, 2001 estimates that up to 60, 000 children born in the USA each year may be affected by mercury toxicity, and in March of 2002 an environmental group had charged the FDA of failing to warn the public of the dangers of mercury contamination from eating tuna, which contain high levels of mercury.

World Health Organization reports that the amount of mercury-absorbed daily by the average human body is 0.3 micrograms (mcg) from water and air, 2.61 mcg from fish, and 17 mcg from dental amalgams (silver fillings). Uptake of up to 100 µg daily has been observed in extreme cases. Research points out that mercury vapor is 80% absorbed into the blood, and that in animal studies, mercury vapor goes directly from the nose to the brain, following nasal nerve pathways. Amalgam fillings release mercury for as long as 70 years. Someone with 8 amalgams could release 120 mcg into the saliva per day.

The maximum allowable by the EPA is less than 0.1 mcg per kilogram of body weight per day, to be absorbed into the human body.

Elemental mercury is found in liquid form, which easily vaporizes at room temperature and is well absorbed through inhalation. Its lipid (fat)-soluble property allows for easy passage through the alveoli into the bloodstream and red blood cells. Once inhaled, elemental mercury is mostly converted to an inorganic divalent or mercuric form by catalase in the red blood cells. This inorganic form has similar properties to organic mercury. Small amounts of non-oxidized elemental mercury continue to persist and account for CNS toxicity. Elemental mercury, as a vapor, which escapes from fillings, penetrates the blood-brain-barrier and enters the CNS, where it’s ionized and trapped, attributing to its significant toxic effects. It is not well absorbed by the GI tract and, when ingested, is only mildly toxic. Inorganic mercury is highly toxic and corrosive and is the most destructive form, but its destruction is limited to where it’s located. It doesn’t have the ability to move through tissues like other forms. It gains access orally or dermally and is absorbed at a rate of 10% of that ingested. It has a nonuniform mode of distribution, secondary to poor fat solubility, and accumulates mostly in the kidney, causing renal damage.

Although poor lipid solubility characteristics limit CNS penetration, slow elimination and chronic exposure allow for significant CNS accumulation of mercuric ions and subsequent toxicity. Chronic dermal exposure to inorganic mercury also may lead to toxicity. Excretion of inorganic mercury, as with organic mercury, is mostly through feces. Renal excretion of mercury is considered insufficient and attributes to its chronic exposure and accumulation within the brain, causing CNS effects. Organic mercury can be found in 3 forms, aryl and short and long chain alkyl compounds. This is 100 times more toxic than the ionic or vapor forms. Bacteria in the mouth, stomach and intestines, or in the blood, through a process called methylation, converts mercury vapor and ionic mercury into deadly methylmercury.

Organic mercurials are absorbed more completely from the GI tract than inorganic salts are; this is because of intrinsic properties, such as lipid solubility and mild corrosiveness (although much less corrosive than inorganic mercury). Once absorbed, the aryl and long chain alkyl compounds are converted to their inorganic forms and possess similar toxic properties to inorganic mercury. The short chain alkyl mercurials are readily absorbed in the GI tract (90-95%) and remain stable in their initial forms. Alkyl organic mercury has high lipid solubility and is distributed uniformly through the body, accumulating in the brain, kidney, liver, hair, and skin. Organic mercurials also cross the blood brain barrier and placenta and penetrate red blood cells, attributing to neurological symptoms, teratogenic effects, and high blood-to-plasma ratios.

Confirmation of the escape of mercury vapor and ions from amalgam dental fillings is provided by The World Health Organization (WHO) Environmental Health Criteria 118 document (EHC 118) on inorganic mercury. It clearly states that the largest estimated average daily intake and retention of mercury and mercury compounds in the general population, is from dental amalgams, not from food or air. Mercury vapor inhaled into the lungs is absorbed almost 100 percent and immediately passes into the bloodstream. It takes approximately four minutes before mercury is converted or oxidized into an ionic state from its elemental vapor state. While in its elemental form, mercury vapor is lipid (fat) soluble and readily passes through the blood-brain barrier or the placental membrane.

It can also accumulate in other organs and tissues of the body. The estimated average daily intake of mercury from dental amalgams is 3.8 – 21 micrograms per day. Two-thirds of the body burden of mercury is derived from the mercury vapor released from amalgams. The static, unstimulated release of mercury vapor from amalgam fillings, which goes on 24 hours a day, 365 days a year, is a major contributor to total mercury body burden. Large amounts of mercury vapor are released during chewing. After only ten minutes of gum chewing, there is an average increase in mercury release of 15.6 times more than during the resting state in test subjects. That converts to a 1,560% increase in mercury release.

“The World Health Organization has calculated that the average human daily dose of mercury from various sources are: Dental amalgam = 3.0-17.0 mg/day (Hg vapor) Fish and Seafood = 2.3 mg/day (methylmercury) Other food = 0.3 mg/day(inorganic Hg) Air & Water = Negligible traces (NOTE mg = Micrograms)” (World Health Organization Figures, from Environmental Health Criteria 118: Inorganic Mercury, Geneva, 1991. These figures confirm Amalgam as #1 average source for Environmental Mercury exposure.)

“You wouldn’t take a leaky thermometer, put it in your mouth, and leave it there 24 hours a day, 365 days a year. Yet that’s exactly what happens when an amalgam filling is installed in your mouth.”–Dr Michael Ziff.

Mercury readily mixes with food and is swallowed with it. The body uptake from inorganic mercury, swallowed with saliva, can be as much as hundreds of micrograms per day for individuals with a large number of amalgam fillings. Urinary excretion is a common indicator of mercury toxicity, even though fecal excretion of mercury is twenty times greater than the corresponding urinary excretion. There is a statistical correlation between the mercury concentration in saliva and the number of amalgam fillings. The United States government has determined and ruled that the continual exposure to mercury from amalgam fillings is not without risk to patients. We are concerned over picograms and micrograms of mercury in apples and are looking the other way when milligrams, one million times more, are being implanted directly into a child’s mouth. There is a phenomenon that occurs in the mouth that can contribute to the release of mercury, and is called corrosion. Corrosion is similar to “rust” and means that surface particles of the filling material are being chemically broken down and released into the oral cavity.

Mercury vapor is released when you chew or grind. Additionally, minute rusted particles of the amalgam are being abraded and taken up by your food or saliva and swallowed. Intestinal enzymes and bacteria both produce methylmercury, an even more toxic form than elemental mercury, may act upon these minute particles of mercury filling. Although several sources contributing to the domestic mercury concentrations have been identified, human wastes (feces and urine) from individuals with dental amalgam fillings are believed to be the most significant source–greater than 80 percent. Conventional amalgam was routinely placed until 1976, when the new state-of-the-art amalgams (50% mercury and 30% copper) were introduced. They emit up to 50 times more mercury than the earlier, conventional amalgam fillings. That means that every new high-copper amalgam filling placed today has the effective toxic equivalent of fifty of the older amalgam fillings. If other fillings are in the mouth, such as gold crowns, nickel crowns, and removable bridges or braces, the mercury emission further increases from the amalgam. This is due to the electrical current generated by the presence of dissimilar metals in an electrolyte such as saliva. Heat will reliably increase the rate of escape of mercury vapor from amalgam fillings. Vapor detectors, held above amalgams, revealed an increase from 3 micrograms to over 500 micrograms ten seconds after a hot drink was swallowed.

“Worldwide there are over 4000 research papers indicating mercury is a highly toxic substance. How can dentists be so thoughtless as to place one of the deadliest toxins in existence *two* inches from our brain?”–Tom Warren

“The mercury uptake from amalgam is the dominating source for inorganic mercury in the central nervous system and is the major source of total mercury uptake in the population.”–Maths Berlin, a leading Swedish toxicologist
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Mercury: The Global Disaster
2018-09-16 19:25:30 by George Detox News, Toxicity
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Scientists around the world have shown how low levels of mercury toxicity is directly related to illnesses like cancer, heart disease and a host of neurological problems like Alzheimer’s, MS, ALS, autism spectrum disorders. It could also be playing an important role in the rapid increases we are seeing in diabetes – mercury attacks sulphur bonds in both insulin and insulin receptor sites.

One only has to do a preliminary search of the literature and find 358 papers exemplifying the relationship between cardiovascular disease and mercury with a further 643 showing the correlation between cancer and mercury. However, degenerative neurological diseases top the list with over 1,445 publications demonstrating a relationship with mercury.

The Institute of Medicine (IOM) and the CDC, and a long string of other medical organizations are certifying mercury as safe for use in vaccinations when there is a plethora of research to suggest the opposite. This safety of mercury is being proposed on the one hand, while on the other the dangerous pandemic of one child in 166 being diagnosed with autism spectrum disorders and as many as one in six children diagnosed with a developmental disorder are blasted across the media.

These figures convert to about 24,000 children born each year in the U.S. alone will be afflicted with autism related to mercury, while perhaps over 600,000 children will suffer from mild to severe learning disorders due to neurological damage of delicate brain cells.

There are many other damaging effects of mercury – here is a list that is backed by scientific research and well referenced:
- Dental Amalgam contains about 50% Mercury
- Mercury has been scientifically demonstrated to be more toxic than Lead, Cadmium, or even Arsenic
- Mercury leaves dental amalgam continuously throughout the lifetime of the filing
- Mercury vapour is the main way that mercury comes out of amalgam
- Mercury vapour is absorbed at a rate of 80% through the lungs into the arterial blood
- Mercury is cytotoxic. Ie. It kills cells
- There is NO harmless level of Mercury Vapour Exposure
- Mercury from amalgam binds to -SH (sulphydryl) groups. These exist in almost every enzymatic process in the body. Mercury from amalgam will thus have the potential of disturbing all metabolic processes
- Mercury from amalgam is transported freely via the blood
- Mercury vapour is absorbed directly into the brain
- Mercury from amalgam will result in a slow build up of mercury in body tissues
- Mercury crosses the blood brain barrier
- Mercury is implicated in the pathogenesis of Alzheimer’s Disease
- Mercury from amalgam is stored in the foetus and infant before the mother
- Mercury from amalgam is stored in the breast milk and the foetus up to 8 times more than the mother’s tissues
- Mercury (Mercury Vapour / Methylmercury) crosses the placenta
- Mercury Crosses into breast milk
- Mercury will severely reduce reproductive function
- Mercury rapidly depletes the immune system
- Mercury will induce a number of Auto Immune Diseases
- Mercury will cause an increase in number and severity of allergies
- Mercury from amalgam is stored principally in the kidneys, liver and brain
- Mercury from amalgam (shown in animal experiments) causes kidney damage
- Mercury from will cause a 50% reduction in Kidney filtration as shown in a study of sheep after amalgam placement
- Methyl Mercury is more toxic than elemental Mercury
- Mercury from amalgam is methylated in the mouth
- After chewing, Mercury Vapour levels will remain raised for at least another 90 minutes
- Mercury from amalgam will migrate through the tooth
- This rate of migration is increased if a gold crown is placed over a tooth filled with amalgam
- Teeth are living tissue and are a part of our bodies
- Teeth have a massive communication via blood, lymph and nerves with the rest of the body
- Mercury from amalgam is absorbed into the body at a rate of 3 to 17 mcg / day
- Mercury release is increased by; increases in temperature, friction & increase in electrical currents
- Mercury from amalgam will enter the body as: Elemental Mercury, Inorganic Mercury, Vapour, charged Mercury ions
- In the Brain, Mercury from amalgam is stored preferentially in the Pituitary Gland and Hypothalamus
- Micro-Mercurialism is principally characterised by Neurological symptoms
- Mercury is transported along the axons of nerve fibres
- Mercury from amalgam may be stored in every other cell in the body. Each area affected will produce its own set of symptoms
- Mercury binds to haemoglobin in the red blood cell thus reducing oxygen carrying capacity
- Mercury damages blood vessel reducing blood supply to the tissues (micro-angiopathies)
- Amalgam fillings produce electrical currents which might be injurious to health. These currents are measurable in Micro Amps. The Central Nervous System (Brain) operates in the range of Nano-Amps this is One Thousand times less than a Micro Amp
- Dissimilar metals in the mouth [eg Gold & Amalgam] will produce higher electrical currents
- Mercury from amalgam (shown in animal experiments) will induce Antibiotic Resistance and Mercury resistance in bacteria in the mouth and Gastrointestinal tract
- Brain levels of mercury are in a direct linear proportion to the number of Surfaces of amalgam fillings in the mouth
- The level of Mercury, in brain tissue of foetus’s, new born, and young children, is proportional to the number of amalgams in the mother’s mouth
- Mercury will cause single strand breaks in DNA
- Mercury levels in the body can not be assessed by either blood or urine levels
- Mercury from amalgam fillings is the single
  greatest source of dietary mercury for the general population
- Dental personnel are severely effected by exposure to mercury
The Solution
As you are all probably aware, there are a number of synthetic and natural products that can chelate mercury. Most of the natural products have not been tested in double-blind, placebo controlled trials except for HMD™ which has been shown to eliminate 448% more mercury in the post-urine sample compared to baseline in 56 people.
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Killing Ourselves with Xenobiotics
2018-09-16 19:22:21 by George Detox News, Toxicity
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Toxic chemicals, otherwise known as “xenobiotics” (Gk: foreign to life) which are scattered all over our planet from the North Pole to the South Pole, are being constantly researched, and the conclusion is that they are extremely toxic to humans as well as wildlife. Even though some chemicals have been taken off the market, those that remain are even more noxious than the ones already banned. Bioaccumulation in soils, water supplies and the tissues of animals and humans is a real problem which results in these chemicals lingering for many, many years even after they have being banned. DDT, for example, has been banned for more than 25 years in the Western world, yet it is still being found in the tissues of wildlife in the arctic, as well as humans in many different countries.

A recent study noted that only five organochlorine compounds and mercury were found in marine mammals in the 1960s. Today over 265 organic pollutants and 50 inorganic chemicals have been found in these species.¹

Recent research has focused on how chemicals affect the thyroid and pituitary systems. Some chemicals have been identified as endocrine disrupters because they can interfere with the body’s own hormones, which are secreted by the endocrine glands.

It is also emerging that endocrine disrupters can have many physiological effects not directly associated with the primary system. For example, the thyroid system is well known to regulate metabolism, but it is also a crucial component in foetal brain development in mammals, and too much or too little thyroid hormone at crucial points can do permanent damage. The immune system is also vulnerable to hormone-mediated disruption. Chemicals can cause neurological problems, reproductive and developmental abnormalities, and cancers as well. And researchers are only just beginning to disentangle the questions about the effects of chronic low-level exposure (as opposed to brief high doses of chemicals), combinations of chemicals, and interactions between chemicals and other physiological and environmental factors.

Let us take a brief look at some of the more common xenobiotics chemicals that that have detrimental effects on humans as well as wildlife.

Perfluorochemicals (PFCs)

These compounds are chains of fully fluorinated carbon atoms of varying lengths, yielding chemicals that are extremely resistant to heat, chemical stress, and that repel both water and oil. Because of these properties PFCs, or chemicals that degrade into PFCs, have been widely used since the 1950s by industry as surfactants and emulsifiers and in commercial products, including stain or water protectors for carpet, textiles, auto interiors, camping gear and leather; food packaging; folding cartons and other paper containers; floor polishes; photographic film; shampoos; dental cleaners; inert pesticide ingredients; and lubricants for bicycles, garden tools and zippers.

Their persistence is extreme, particularly perfluorooctanoic acid (PFOA) – there is no evidence that they ever fully degrade, and they have been found in animals, humans and ecosystems worldwide.

The first public indication that PFOS and PFOA were problematic came on May 16, 2000 when 3M, the primary global manufacturer of many perfluoroalkanesulfonates and PFOA, announced plans to phase out by the end of 2001 the production of perfluorooctanyl chemistry that underpinned their extremely successful Scotchgard™ and Scotchban™ product lines.²

A 2002 European study of PFCs has detected these compounds in bottlenose, common and striped dolphins, whales, bluefin tuna, swordfish and cormorants in the Mediterranean, and in ringed and grey seals, sea eagles and Atlantic salmon in the Baltic.³

Other research shows that this chemical is now contaminating many wildlife species around the world, including polar bears in the Arctic, seals in Antarctica, dolphins in the river Ganges in India, albatrosses from Midway Atoll in the Pacific, turtles in the United States, gulls in Korea, cormorants in Canada,⁴ and fish in Japan.⁵

Fluorinated telomers are used to keep grease from soaking through fast food containers such as pizza boxes, French fry holders, and food wrapping paper. The digestive system can break telomers down into PFOA and related chemicals. Newly revealed tests conducted by 3M showed that a metabolite specific to the telomers was found in 85 per cent of the children tested.⁶

Red Cross blood banks, conducted by a team including scientists from the 3M Company, estimated the average concentrations in humans to be 30-40 parts per billion (ppb), with males having higher levels.⁷ By comparison, levels in wildlife have been measured at 940 ppb in common dolphin liver; 1100 ppb in ringed seals from the Bay of Bothnia; and 270 ppb in long-finned pilot whale liver from the North Thyrrenian Sea.⁸

Health Effects of Perfluorochemicals (PFCs)

In 1979, 3M administered four doses of PFOS to monkeys and all the monkeys in all treatment groups died within weeks. Typically, when a study like this is conducted, the researchers predict that the lowest dose will not cause any harmful health effects.⁹

In 1981 both DuPont and 3M reassigned women of childbearing age working in their production plants after they learned that PFOA caused developmental abnormalities in laboratory animals. Within weeks of this discovery, DuPont found PFOA in the women’s blood.

It was known as early as 1975 that fumes from hot pans coated with polytetrafluoroethylene can kill pet birds,¹⁰ and broiler chicks have died after exposure to polytetrafluoroethylene-coated light bulbs.¹¹ Laboratory experiments reported in 2003 showed that in rats, PFOS exposure can lead to loss of appetite, interrupted oestrus cycles, and elevated stress hormone levels. PFOS was found to accumulate in brain tissue, particularly the hypothalamus, suggesting that PFOS crosses the blood-brain barrier and may interfere with reproductive hormones through the pituitary-hypothalamus process that stimulates their production.¹²

Recent laboratory studies with PFOA involving rats show low birth weight, small pituitary gland, altered maternal care behaviour, high pup mortality, and significant changes in the brain, liver, spleen, thymus, adrenal gland, kidney, prostate, testes and epididymides.¹³

Several studies indicate PFOA increases estrogens and leads to testosterone dysfunction in males. There is even more evidence that PFOA as well as chemicals that metabolize to PFOs and PFOA lead to underactive thyroid; thyroid dysfunction during pregnancy can lead to many developmental problems, including faulty brain development and neurological and behavioural problems that affect not only infants and young animals (or humans) but continue into adulthood. The EPA considers both PFOS and PFOA to be a carcinogen in animals, with testicular, pancreatic, mammary, thyroid and liver tumours most frequent in exposed rats.

All studies to date indicate perfluorinated compounds damage the immune system. In one experiment, a chemical very similar to PFOA called PFDA resulted in such atrophy of the thymus gland, (the source of T cells that attack bacteria, viruses and cancer cells) that the gland was undetectable upon clinical examination.

Phthalates

Phthalates are a group of chemicals used as softeners in a variety of plastic products, including the ubiquitous polyvinyl chloride (PVC). Products containing phthalates include medical devices (intravenous tubing, blood bags, masks for sleep apnea devices), building products (insulation of cables and wires, tubes and profiles, flooring, wallpapers, outdoor wall and roof covering, sealants), car products (car under-coating, car seats etc.) and children’s products (teething rings, squeeze toys, clothing and rainwear). They are also used in some lacquers, paints, adhesives, fillers, inks and cosmetics.

The most common phthalate in the environment is di-(2-ethylhexyl)phthalate (DEHP), which comprises half of all phthalates produced in Western Europe, with 450,000 tonnes used per year. Concern about children’s exposure to phthalates prompted the EU to ban six types of phthalate softeners in PVC toys designed to be mouthed by children under three years of age.

Both humans and wildlife may be exposed to various phthalates. For example, a 2003 study of two groups of pregnant women, one in New York City and one in Krakow, Poland, compared the levels of four phthalates in the women’s personal ambient air and measured the levels of the metabolites of these phthalates in the urine of the New York women.¹⁴ All four phthalates were present in all the air samples, but air concentrations of DBP, di–isobutyl phthalate and DEHP were higher in Krakow than in New York. The study found that air was a significant source of exposure, that some women receive doses high enough to cause concern, and that there was a correlation between air and urine levels of some phthalates.

Other studies in the EU have also raised concerns with regard to current exposure levels. A recent study in Germany, for example, has concluded that exposure to DEHP may be far higher than previously thought. It reported that in 12 per cent of the Germans studied, phthalate levels exceeded the tolerable daily intake (TDI) used by the EU Scientific Committee for Toxicity, Ecotoxicity and the Environment. Exposure to DBP and BBP was also ubiquitous.¹⁵

Health Effects of Phthalates

Some phthalates appear to exert endocrine disrupting effects, and can act against the male hormone, androgen, through pathways other than binding to androgen or estrogen receptors. While there is little research on the effects of phthalates on wildlife per se, some studies suggest that there may be serious consequences for both wildlife and humans. Of particular concern is phthalate exposure in pregnant females: some researchers have proposed that the antiandrogenic properties of phthalates might be linked to testicular dysgenesis syndrome, the manifestations of which range from birth defects in males, including undescended testes, to low sperm counts and testicular cancer.¹⁶

Numerous Laboratory studies underpin the concern. For example, a study has shown that DEHP, BBP, and DINP administered to pregnant rats induced feminized breasts in the male offspring, as well as other reproductive malformations, including small testes in the case of the DEHP and BBP.¹⁷

There are also worries that exposure to manmade chemicals with hormone disrupting properties may be affecting the age of puberty. A study of Puerto Rican girls with premature breast development suggested a possible association with exposure to certain phthalates.¹⁸ U.S. researchers recently reported the effects of DEHP on Leydig cells (testosterone-producing cells in the testes) in rats.¹⁹ They found that prolonged exposure to DEHP caused the number of Leydig cells to increase by 40 per cent-60 per cent while simultaneously reducing testosterone production. At the same time, blood levels of both testosterone and estrogens increased by 50 per cent. It is known that males with high levels of serum testosterone and luteinizing hormone (a hormone that triggers testosterone production) are at higher risk of early puberty and testicular tumours.

With regard to cancer, a recent study supported other research associating DEHP with liver cancer in rodents.²⁰ A 2003 Harvard study suggested another mechanism for carcinogenic effect of phthalates. The researchers measured levels of eight phthalates in subjects and found an association between monoethyl phthalate (MEP) and increased damage to the DNA in the subjects’ sperm.²¹ This is the first study showing that phthalates can induce such damage at levels presently found in the environment.

Other studies with phthalates show that additive effects can occur when there is exposure to more than one phthalate.²² This underlines the growing concern with real life exposures to multiple pollutants, and the increasing realisation that current regulatory practices, based on testing chemicals in isolation, may not be protective.

Phenols, Bisphenyl A and Nonylphenol

Evidence for endocrine disruption by the widely used phenol compounds bisphenol A (BPA) and nonylphenol is mounting. BPA is mostly used to make polycarbonate plastic, which has a diverse range of application in making bottles, computer and electronics shells, CDs, crash helmets, and many other consumer products.

Certain compounds that can leach BPA are also used in the plastic linings of food cans and in dental fillings, through which people can ingest small quantities. In December 2003, concerned about BPA in the plastic linings of food cans, the EU reduced the amount of BPA migration permitted by 80 percent to 0.6 milligrams per kilogram of food.²³ However, BPA remains widely distributed in consumer products.

Nonylphenolic compounds have been used in degreasing solutions, and in leather and textile processing, as well as in de-icing fluid, paints, plastics, and pesticides. The EU has imposed restrictions on the marketing and use of nonylphenol and nonylphenol ethoxylates to a certain extent in cleaning products, textile and leather processing, agricultural teat dips, metal working, pulp and paper, cosmetics including shampoos, and personal care products except spermicides.²⁴

Health Effects of Phenols

Fish have been shown to be susceptible to the endocrine disrupting effects of both nonylphenol²⁵ and BPA.²⁶ Exposure to either of these chemicals can cause male fish to make vitellogenin (an estrogen-regulated protein produced by female egg-laying vertebrates and not normally produced by males or juveniles), and can also affect the formation of sperm. Before improved regulation, male fish in the river Aire in England were found to be feminised downstream of a wastewater treatment plant discharge containing alkylphenol ethoxylates from the textile industry. Many male fish were found with egg producing cells in their testes, and reduced testis growth rate and size.^27,28

Aquatic invertebrates seem particularly sensitive to these chemicals. For example, nonylphenol affects the freshwater algae, Scenedesmus subspicatus at levels of 3.3 micrograms per litre.²⁹ Molluscs in particular have shown effects at very low dose levels. For example, in the mollusc Potamopyrgus antipodarum, BPA and octylphenol, as well as a mixture of these and other chemicals in treated sewage effluent, stimulated egg and embryo production at low doses and inhibited such production at high doses.³⁰

This work supported a 2000 study by some of the same researchers showing that extremely low levels of BPA and octylphenol triggered malformed genitals of female ramshorn (freshwater) snail, Marisa cornuarietis, and the (saltwater) dogwhelk Nucella lapillus.³¹ In some of the freshwater snails, the excessive growth of the female glands and the egg masses ruptured the egg tube, and the snails died. This syndrome was referred to as superfeminisation. A number of other adverse changes were observed in both species. Another important finding was that in the freshwater snails, the medium doses of octylphenol produced more changes than either the highest or lowest doses.

Other researchers have shown that a single 48-hour exposure to 1 microgram per litre of nonylphenol, comparable to environmental levels, altered the sex ratio of oysters, reduced the survival of offspring, and caused some oysters to become hermaphroditic.³²

A 2001 study exposing barnacles to concentrations of nonylphenol similar to those in the environment (0.01-10 micrograms per litre) disrupted the timing of larval development.³³ In addition to fish, other vertebrates also show effects when exposed to BPA. For example, in 2003, researchers reported that BPA at environmentally comparable doses resulted in sex reversals and altered gonadal structures in the broad-snouted caiman, an alligator relative native to mid-latitude South America.³⁴ In another study, the offspring of pregnant mice exposed to BPA showed changes in ovarian and mammary gland tissues and disrupted fertility cycles as adults.³⁵ BPA was reported for the first time in 2001 to induce reproductive malformations in birds – specifically, in female quail embryos and male chicken embryos. The female embryos’ oviducts developed abnormally, and the males’ testes were feminized.³⁶

The exact mechanism by which BPA and nonylphenol exert their effects is not clear, but a recent in vitro study demonstrated a molecular mechanism by which BPA and nonylphenol interfere with both the activation and function of cellular androgen receptors.³⁷ In a 2002 study, nonylphenol tested on barnacle larvae induced DNA damage, possibly including mutations, and the authors speculate that this effect may be a mechanism by which higher level reproductive abnormalities are caused.³⁸

Despite evidence from these and other studies, the low dose effects of BPA are still in dispute. Regulators in the EU have been reluctant to act, and further studies have been demanded.

Polybrominated Flame Retardants

Brominated flame retardants (BFRs) in furniture, building material, and clothing have become a serious concern, as their levels are showing sharp increases in living organisms. The first BFRs were taken off the market in the early 1970s after a spill led to poisonings of livestock and farm families in Michigan.39 Three BFRs now dominate the market: TBBPA, the most widely used, primarily in printed circuit boards and in some plastics; HBCD, and the deca-BDEs. The other commercial PBDEs (octa-BDE and penta-BDE) have been banned in the EU as of August 2004,⁴⁰ and the state of California has taken similar action. However, because of their alarming spread and rate of accumulation in humans and animals, Europe’s ban does not provide complete reassurance, particularly regarding the penta-BDE form used as a flame retardant in polyurethane foam elsewhere in the world.

Researchers recently reported levels of PBDEs in U.S. breast milk.⁴¹ Forty-seven Texas women had an average level of 73.9 ng/g lipid; such levels are sharply higher than those found in European studies. There are serious concerns about the transfer of BFRs to nursing infants, and some scientists are worried that BFRs might affect foetal development, including disruption of the thyroid system’s role in foetal brain development.⁴² In 2003 a WWFUK biomonitoring program found deca-BDE in the blood of seven per cent of those tested.⁴³

New research from Sweden has found high levels of several brominated flame retardants in the eggs of peregrine falcons from 1987-1999. The eggs of falcons living in the wild had significantly higher concentrations of the essentially unregulated deca-BDE than eggs of captive falcons. The fact that deca-BDE was found in eggs demonstrates that the chemical can cross cell membranes, contrary to what scientists had previously thought. The peregrine study represents the first time that the deca formulation has been found in wildlife.⁴⁴

In 2002, one research team predicted that within 10 to 15 years, concentrations of BFRs in Great Lakes herring gull may be higher than those of PCBs.⁴⁵ BFRs have also been found in sperm whales,⁴⁶ ringed seals from the Canadian Arctic,⁴⁷ mussels and several kinds of fish in Norwegian waters, and harbour seals in San Francisco Bay,⁴⁸ among other wildlife. Essentially, BFRs are being found wherever we look.

Health Effects of BFRs

Laboratory studies show that certain BFRs are highly toxic to aquatic animals (crustaceans),⁴⁹ and suggest effects on pubertal development, thyroid and liver in rats, as well as developmental neurotoxicity in mice.⁵⁰ A recent paper reported behavioural effects in mice pups at a relatively low dose.⁵¹ In 1999 Swedish researchers reported that PBDEs and HBCD may have health effects similar to those of DDT and PCBs because of their ability to induce genetic recombination.⁵²

While there are no published epidemiological studies on effects of BFRs on humans, the possible thyroid effects, based on tissue culture and animal studies, are a red flag. As with other chemicals, anything that affects foetal development merits particular study because of the profound, long-term, and often irreversible influence that early exposures have on the entire life of an organism.

What Can We Do To Protect Ourselves?

The answer to this question is two-fold; first we can push for legislation to ban a lot of these harmful chemicals that have been researched and are known to be detrimental to animals and humans. Second, we need to be able to detoxify our bodies in order to eliminate many of these chemicals. Given that we are exposed to these literally daily, this process must be an ongoing one. It is not safe to use chemical chelators on an ongoing basis, but natural ones can be used instead, much like a supplement on a daily basis. HMD™ can be used safely over long periods of time with no side effects – it is presently being tested to see its efficacy in eliminating some of the xenobiotics mentioned in this article.

References

1 O’Shea, T.J., Tanabe, S., Persistent ocean contaminants and marine mammals: a retrospective overview. In: O’Shea, T.J. et al. (Eds.), 1999. Proceedings of the Marine Mammal Commission Workshop Marine Mammals and Persistent Ocean Contaminants, pp 87-92. (cited in Tanabe, S. Contamination and toxic effects of persistent endocrine disrupters in marine mammals and birds. Mar Pollut Bull 2002;45:69-77.)

2 3M. (2000) 3M phasing out some of its specialty materials, May 16, 2000 press release.

3 Kannan, K., Corsolini, S., Falandysz, J., Oehme, G., Focardi, S., Giesy, J.P. Perfluorooctanesulfonate and related fluorinated hydrocarbons in marine mammals, fishes and birds from coasts of the Baltic and Mediterranean Seas. Environ Sci Technol 2002 Aug 1;36(15):3210-6.

4 Geisy J.P. and Kannan K. Global Distribution of Perfluorooctane sulfonate in wildlife. Env Sci Technol 2001, 35:1339-42.

5 Taniyasu, S., Kannak, K., Horii,Y., Hanari, N.,Yamashita, N. A survey of perfluorooctane sulfonate and related perfluorinated organic compounds in water, fish, birds and humans from Japan. Environ Sci & Technol 2003, 37:2634-2639.

6 Fields, S. Another fast-food fear. Environ Health Perspect 2003: 111:16:A162.

7 Olsen, G. W., Church, T.R., Miller, J.P., Burris, J.M., Hansen, K.J., Lundberg, J.K., Armitage, J.B., Herron, R.M., Medhdizadehkashi, Z., Nobiletti, J.B., O’Neill, E.M., Mandel, J.H., Zobel, L.R. Perfluorooctanesulfonate and other fluorochemicals in the serum of American Red Cross adult blood donors. Environ Health Perspect 2003:111:1892-1901. doi.10.1289/ehp.6316 via http://dx.doi.org.

8 Kannan, et al., 2002.

9 Organization for Economic Cooperation and Development (OECD). (2002) Hazard Assessment of perfluorooctane sulfonate (PFOS) and its salts (November, 21 2002). ENV/JM/RD(2002)17/FINAL. Available online at: http://www.oecd.org/dataoecd/23/18/2382880.pdf

10 “PFCs: A Family of Chemicals that Contaminate the Planet,” Part 6: PFCs in Animals Worldwide. Environmental Working Group, 2003. http://www.ewg.org/reports/pfcworld/part8.php Accessed 3 January 2004.

11 Ibid.

12 Austin, M.E., Kasturi, B.S., Barber, M., Kannan, K., MohanKumar, P.S., MohanKumar, S.M.J. Neuroendocrine effects of perfluorooctane sulfonate in rats. Environ Health Perspect 2003:111:12:1485-1489.

13 Thayer, K., Klein, J. Gray, S., Houlihan, J.,Wiles, R., Greenleaf, T., PFCs: A Family of Chemicals that Contaminate the Planet. Environmental Working Group 2003. http://www.ewg.org/reports/pfcworld/part4.php Accessed 5 January 2004.

14. Adibi, J.J., Perera, F.P., Jedrychowski,W., Camann, D.E., Barr, D., Jacek, Ryszard, Whyatt, R.M. Prenatal exposures to phthalates among women in New York City and Krakow, Poland. Environ Health Perspect 2003:111:14:1719-1722.

15 Kock et al, 2003. An estimation of the daily intake of di(2-ethyl) phthalate (DEHP) and other phthalates in the general population. International Journal Hygiene and Environmental Health.

16 Sharpe R.M. (2003). The oestrogen hypothesis – where do we stand now? International Journal of Andrology 26:2-15; Skakkebaek, N.E. et al., (2001) Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Human Reproduction 2001:16:5:972-978.

17 Gray, L.E. Jr., Ostby, J., Furr, J., Price, M., Veeramachaneni, D.N., Parks, L. Perinatal exposure to the phthalates DEPH, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicological Sciences 2000:58:350-565.

18 Colón, I., et al., Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development. Environmental Health Perspectives, 108(9): p. 895-900.

19 Akingbemi, B.T., Ge, R., Klinefelter, G.R., Zirkin, B.R., Hardy, M.P. Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances. Proceedings of the National Academy of Sciences 2004 (Early Edition). www.pnas.org/cgi/doi/10.1073/pnas.0305977101 , accessed 31 December 2003.

20 Seo, K.W., Kim, K.B., Kim,Y.J., Choi, J.Y, Lee, K.T., Choi, K.S. Comparison of oxidative stress and changes of xenobiotic metabolizing enzymes induced by phthalates in rats. Food Chem Toxicol. 2004 Jan;42(1):107-14.

21 Duty, S.M., Singh, N.P., Silva, M.J., Barr, D.B., Brock, J.W., Ryan, L., Herrick, R.F., Christiani, D.C., Hauser, R. The relationship between environmental exposures to phthalates and DNA damage in human sperm using the neutral comet assay. Environ Health Perspect 2003 111:9:1164-1169. http://ehp.niehs.nih.gov/members/2003/5756/5756.html , accessed 6 January 2004.

22 Foster, P M. Turner K J, Barlow N J. Anti-androgenic effects of a phthalate combination on in utero male reproductive development in the Sprague-Dawley rat: additivity of response? Toxicologist 2000 Mar; 66(1-S), 233.

23 Environmental Data Services, Ends Daily 15th Dec 2003.

24 DIRECTIVE 2003/53/EC OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 18 June 2003 amending for the 26th time Council Directive 76/769/EEC relating to restrictions on the marketing and use of certain dangerous substances and preparations (nonylphenol, nonylphenol ethoxylate and cement), Official Journal L 178 17-7-2003

25 Jobling S., Sheahan D., Osborne J., Matthiessen P., Sumpter J. (1996). Inhibition of testicular growth in rainbow Trout (Oncorhynchus mykiss) exposed to oestrogenic alkylphenolic chemicals. Environ. Toxicol. Chem., 15, 194-202.

26 Sohoni et al, Reproductive effects of long term exposure to bisphenol A in the fathead minnow (Pimephales promelas), Environ Sci Technol 2001:35: 2917-2925.

27 Environment Agency of England and Wales 1998; Endocrine Disrupting Substances in the Environment. What Should Be Done? The EA Bristol.

28 Commission of the European Communities. Proposal for a Directive of the European Parliament and of the Council relating to the restrictions on the marketing and use of nonylphenol, nonylphenol ethoxylate and cement. COM (2002) 459, 2002/0206 (COD).

29 Kopf W. Wirkung endokriner stoffe in biotests mit wasserogranismen. In Stoffe mit endokriner wirkung in wasser. Bayerisches landesamt für wasserwirtschaft, Institut für Wasserforschung München (ed) Oldenbourg (1997) (as detailed in the European Union Risk Assessment Report (2002) 4-NONYLPHENOL (BRANCHED) AND NONYLPHENOL, CAS Nos: 84852-15-3 and 25154-52-3 EINECS Nos: 284-325-5 and 246-672-0, Joint Research Centre, European Commission).

30 Jobling, S., Casey, D. Rodgers-Gray, T., Oehlmann, J., Schult-Oehlmann, U., Pawlowski, S., Baunbeck, T., Turner, A.P., Tyler, C.R. comparative responses of molluscs and fish to environmental estrogens and an estrogenic effluent. Aquat Toxicol 2003 Oct 29;65(2):205-20.

31 Oehlmann, J., Schulte-Oehlmann, U., Tillmann, M., Markert, B. Effects of endocrine disruptors on Prosobranch snails (Mollusca: Gastropoda) in the laboratory. Part I: Bisphenol A and octylphenol as xenoestrogens. Ecotoxicology 2000 9:383-397.

32 Nice, H.E., Morritt, D., Crane, M. Thorndyke, Long-term and transgenerational effects of nonylphenol exposure at a key stage in the development of Crassostrea gigas. Possible endocrine disruption? M. Marine Ecology Progress Series, 2003 256:293-300.

33 Billinghurst, Z., Clare, A.S., Depledge M.H. Effects of 4-n-nonylphenol and 17beta-oestradiol on early development of the barnacle Elminius modestus. J. Exper. Mar. Biol. Ecol. 2001: Mar 15;25(2);255-268.

34 Stoker, C., Rey, F. Rodriguez, H., Ramos, J.G., Sirosky, P., Larriera, A., Luque Munoz-de-Toro, M. Sex reversal effects on Caiman latirostris exposed to environmentally relevant doses of the xenoestrogen bisphenol A. Gen Comp Endocrinol 2003 Oct 1;133(3)287-96.

35 Markey, C.M., Coombs, M.A. Sonnenschein, C., Soto, A.M. Mammalian development in a changing environment: exposure to endocrine disruptors reveals the developmental plasticity of steroid hormone target organs. Evol Dev 2003 Jan-Feb;5(1):67-75.

36 Berg, C., Halldin, K., Brunstrom, B. Effects of bisphenol A and tetrabromobisphenol A on sex organ development in quail and chicken embryos. Environ Toxicol Chem 2001 Dec;20(12):2836-40.

37 Lee, H.J., Chattopadhyay, S., Gong, E-Y, Ahn, R.S, Lee, K. Antiandrogenic effects of bisphenol A and nonylphenol on the function of androgen receptor. Toxicological Sciences 2003 75:, 40-46.

38 Atienzar, F.A., Billinghurst, Z., Depledge, M.H. 4-n-Nonylphenol and 17-beta estradiol may induce common DNA effects in developing barnacle larvae. Environ Pollut 2002;120(3):735-8.

39 Dunckel (cited in Birnbaum, L., Staskal, D.F. Polybrominated flame retardants: cause for concern? Environ Health Perspect 2004:112:9-17. doi10.1289/ehp.6559. available via dx.doi.org. Accessed 5 January 2004.

40 Official Journal of The European Union, L 42/45 Feb. 15, 2003.

41 Schecter, A. Pavuk, M. Papke, O., Ryan, J.J., Birnbaum, L., Rosen, R. Polybrominated diphenyl ethers (PBDEs) in U.S. mothers’ milk. Environ Health Perspect 2003:111:14:1723-1724.

42 http://www.ourstolenfuture.org/NewScience/oncompounds/PBDE/2003/2003-0807schecteretal.htm Accessed 5 January 2004.

43 http://www.panda.org/about_wwf/where_we_work/europe/what_we_do/policy_and_events/epo/news.cfm?uNewsID=9941 Accessed 8 January 2004.

44 Lindberg, P., Sellström, U., Häggberg, L., and de Wit, C.A. Higher brominated diphenyl ethers and hexabromocyclododecane found in eggs of peregrine falcons (Falco peregrinus) breeding in Sweden. Environ Sci Technol 2004:38;(1): 93-96.

45 Norstrom RJ, Simon M, Moisey J,Wakeford B,Weseloh D.V. Geographical distribution (2000) and temporal trends (1981-2000) of brominated diphenyl ethers in Great Lakes herring gull eggs. Environ Sci Technol. 2002 Nov 15;36(22):4783-9.

46 De Boer, J.,Wester, P.G., Klamer, H.J.C., Lewis,W.E., Boon, J.P. Do flame retardants threaten ocean life? Nature 1998:394:28-29; doi:10.1038/27798

47 Ikonomou et al., 2002a (cited in Birnbaum & Staskel, 2004).

48 Birnbaum & Staskal, 2004.

49 Birnbaum & Staskal, 2004.

50 Birnbaum & Staskal, 2004.

51 Darnerud, P.O. Toxic effects of brominated flame retardants in man and in wildlife. Environ Int 2003 Sep;29(6):841-53.

52 Helleday, T., Tuominen, K.L., Bergman, A., Jenssen, D. Brominated flame retardants induce intragenic recombination in mammalian cells. Mutat Res 1999:Feb 19;439(2):137-47. Adapted by the article written by the World Wildlife Fund (WWF) entitled “Cause for Concern: Chemicals and Wildlife. http://www.wwf.org.uk

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I know your products WORK!,

I know your products WORK!

The following testimonials have been sent to us by satisfied HMD™ customers as well as practitioners who are prescribing our products. If you would like to share your story, please email us at admin@detoxmetals.com

Kelly E (MN, USA): ‘I just wanted to say THANK YOU! I know your products WORK!’ Chronic fatigue
I just wanted you fine folks to know that following a hair analysis, which showed I was dangerously high in mercury and uranium, I took a two month course of HMD™. I then took a break for a year (I know..) and reordered, and took almost 3 more months of your HMD™ products. Afterwards I did a follow up hair analysis which showed NO MERCURY and only a trace uranium. I struggle with Chronic Fatigue as well as a chronic spontaneous CSF leak... SO, my health journey began when, per the conventional medical community's own lips, my doctors could do nothing more for me... SO GLAD, or else I would never have researched for myself alternative methods and would probably just be on a ton of drugs, poisoning myself and getting sicker. With that said, getting heavy metals out of my body produced less of a foggy brain for me!!! I didn't just have hair analysis lab results to prove my HM clearance, but my alleviated brain fog told me as well. So I just wanted to say THANK YOU! I know your products WORK!

Adrian (Spain): ‘I am feeling better with every decrease in mercury’ Severe depression and anxiety
In June 2012 I went to see a dentist for a general check up. He told me I needed a filling in a tooth to which I agreed, however I didn't realize the tooth had a mercury filling. The dentist gave me no indication that the tooth had a mercury filling and went about drilling into the filling without any protection or precautions for the mercury being absorbed by myself. Following that appointment I began to get extremely sick, mentally. I began having massive depression and anxiety, so severe that I had to sleep locked in a room on my own without any sharp instruments because I was worried I would harm myself or someone else. The thoughts I was getting were horrific and I couldn't see how I could live thinking like that. It was like my brain was cramping and I was getting horrible thoughts that I just could not control. It was a real battle just to get through one day. In fact I would have to plan the entire day and make sure I had something to do at every stage of day just to help me get through the day. I went to the doctor to try to find the problem. The doctor sent me for blood tests, an epilepsy test, a brain MRI, a cat scan of my head. I went to a maxofacial specialist, an ear nose and throat specialist and a psychiatrist. None of the tests or specialists could find anything so the doctor prescribed me high dose Vitamin B told me to exercise and sent me home. That night I took a vitamin B tablet and woke up at 1:00 feeling like I was dying. Apparently Vitamin B turns mercury into its lethal form of mercury so I stopped taking that immediately. As a person who had always taken extreme care of my health, I couldn't believe how sick I was and plenty of people were telling me that it was just stress. I knew it wasn't stress and with the doctor being ineffective I kept trying to find out why I was so sick. I took food tolerance tests, hormone tests, urine metal tests, allergy tests etc. I eventually sent some hair away for analysis and it came back that I had quite high levels of mercury. That is when things began to click and I realized mercury was the thing that was making me so sick. As it is super toxic. To confirm the test results I went and got a blood test and yes the blood test results also showed high levels of mercury. At this point I did some research and found the natural detoxification product HMD™ which had been well researched and it looked quite impressive. My only concern was its ability to get the mercury out of the brain tissue as all my research suggested that mercury had a strong affinity for brain tissue and my brain was going crazy so I desperately needed that fixed. While I couldn't find any strong research evidence on the ability of HMD™ to remove mercury from brain tissue, Dr George from HMD™ suggested that this may have been the case from anecdotal evidence as his patients experienced better mental health as the HMD™ lowered their mercury levels. That was good enough for me as I was in all sorts of distress. So my action plan was to remove all mercury fillings safely. I found a dentist that did the procedure safely and had all my 4 mercury fillings removed. This also resulted in the removal of a tooth as the bacteria had gotten into the root and my research on root canal therapy showed it to be quite dangerous in the long term. My new dentist did not want to remove the fillings as he said it was more dangerous to take them out then to leave them in but again I had a very strong opinion and proof that I was having issues with mercury. The mercury filling removal was completed by December 2012. I purchased HMD™ and began taking it immediately along with some natural supplements that I read should help with the detoxification and elimination of mercury from my body. I began with 30 drops 3 times per day with the HMD™ but I seemed to be getting sicker so on the advice of the HMD™ team I backed off to 5 drops 3 times a day. I added some extra drops per day as I felt my body was coping with the mercury removal. I tried to get the dosage up to the recommended 45 drops 3 times per day but every time I went over 30 drops 3 times a day I started to feel sick so I stuck with the 30 drops 3 times per day because my body was tolerating that. I knew it would take longer for the mercury to clear but I didn't want to feel so sick all the time. The issue with trying to detox from mercury is that trying to remove it too quickly actually results in the mercury being reabsorbed and re-poisoning you. I realized that was why I was feeling so sick on the higher doses of HMD™ so I kept to the 30 drops 3 times per day. The other supplements I used were vitamin C, Vitamin E, Chlorella, zinc, magnesium and garlic as my research suggested these could help. I tried other supplements along the way but if I felt like they weren't helping I would stop taking them and over time I remained with the supplements I have mentioned. As of April 2013 my mercury had dropped to 9 units So I was detoxing about 1 unit per month which was nice and steady and I was happy as I was gradually feeling better and thinking better. Still my thoughts weren't all clear and happy yet. As of June 2013 I was still at 9 units of mercury in my blood which meant it hadn't dropped in 3 months. I thought this was odd and I was disappointed but I kept on pushing on. As of August 2013 my blood mercury had dropped to 7 units and the mercury was clearing again and with every decrease in blood mercury I was feeling better in the body and head. I was now beginning to function more like normal but still getting the odd strange thought although they weren't nearly as strong. Yes I was definitely improving. I continued to research mercury removal and decided to take the HMD™ on a 4 on 3 day off cycle per week but still taking only 30 drops 3 times per day because anything higher still makes me feel sick. I am also continuing to take the supplements. As of November 2013 my blood mercury is down to 4 units and I am noticing that I am feeling better with every decrease in mercury. It is now that I lift the HMD™ dosage to 40 drops 3 times a day as the increase I can tolerate well. I am hoping in the next 3 to 4 months I will be mercury free. I will continue to detox with HMD™ and update this article as I progress.

Kayla, (US): “This detox has healed my body.” Interstitial cystitis & Lifelong cystic acne
I have been dealing with what doctors label as Interstitial Cystitis(IC) for over a year. I saw two OB/GYNs, an urologist, and a natural doctor. None of which could tell me anything more than it sounded like IC. They stated there are tests they can do, but they are invasive and painful and not always accurate. In all my research of my symptoms and of IC, all I was able to determine was it was inflammation of the bladder. They didn't know what caused it or how to treat/cure it. Finally I met with a holistic nutritionist. I told him my symptoms, and within five minutes he told me what was wrong and how to fix it. I had heavy metal poisoning from mercury fillings (amalgam fillings) from when I was a kid. The symptoms had surfaced because I had begun making changes in my life and moving towards a more healthy, holistic, organic lifestyle, and through this process my body started trying to fight the heavy metal. My nutritionist believes the metal had taken residence in my pancreas and kidneys since I was a child, but my body started trying to flush it out, so it began moving down into my bladder thus inflaming it. He recommended HMD™ and told me if he was right I would notice a different in three months. He was wrong, I noticed a difference within the month. It has now been a little over three months, and I would say I am 99% healed. I plan to do the detox for three more months to ensure it is all gone, but this detox has healed my body. Four months ago, I couldn't sleep at night worrying about what was happening to my body. Now I am perfectly healthy living a normal life. I should also mention I could not wear most silver jewelry because it gave me rashes. Now I can wear just about any jewelry I want. On top of that I have suffered from cystic acne most of my life. I always felt on the verge of a breakout. Three months into this detox and I barely break out anymore, and I haven't had a cystic break out in at least two months. My nutritionist said the metal was inhibiting the good bacteria from fighting off the bad bacteria in my body. I am truly thankful for this product, and I don't want to think about where my life would be without it. Thanks, Kayla

Susanne (Spain): Really a good product and the best money I have spent in a long time. GENERAL ILL HEALTH DUE TO AMALGAM FILLINGS
I just want to say that the HMD™ detox is working very very good with me...After the first week I had kind of flu symptoms but after that I began feeling better. I also had pain flashes in some of my teeth but that has gone too now and I am feeling overall better. My hair has started growing again, skin and my eyes look clearer and more healthy as well. I haven't slept as well for years as I do now after 10 days on the metal detox. It is really a good product and the best money I have spent in a long time.

Michelle (Sacramento, USA): Amazing progress! Mitochondrial dysfunction
The HMD™ products are being used by our vaccine-damaged daughter. She was diagnosed with Mitochondrial Dysfunction. Since starting HMD™, we have noticed many progressive steps. Her eye contact and cognition improved dramatically. She is using more language then ever before. Her bowel movements have been consistent without yeasty stools. This product has definitely changed her overall health and well-being. And she seems so much happier!!! I am so glad her doctor recommended this for her and will NEVER consider removing it from her regimen. Thank you, thank you, thank you!!!

Cynthia (USA): Uranium levels reduced by half! Uranium exposure
Our family apparently was exposed to uranium because it appeared in hair analysis and urine tests. We discovered we lived in an area where there were veins of uranium running underground through the town and later read in news accounts that the EPA was testing wells for uranium in our area. As soon as we learned that we apparently had been exposed, we tried HMD™. It was a relief to know that there were options for detoxification, especially for our children, that wouldn't be harmful. Later testingshowed that the levels had reduced by half in about 6 months. I have recommended HMD™ to friends with autistic children.

Ingrid (UK): Expensive but worth it! Severe Menopause, insomnia, migraine
I have been suffering from severe menopausal symptoms as well as migraines andinsomnia for some time now. A few months ago I stumbled across the HMD™ website and was intrigued. I am a nurse and am very much into natural remedies and holistic healing. But to be honest at first I was really put off by the price. This product is not cheap. After some umming and ahing I finally went for it, and wanted to share my experience here. I went into menopause a few years back. My hot flashes came first and got really intense. It was so bad that sweat was literally dripping down my nose - very embarrassing at work. Within the second year I started not being able to sleep at night I would lay awake for hours and my mood also started to change. I got very irritable and short tempered and this was not nice for my family. Sometimes I would even carry it into work and be slight short tempered with my colleges, which I had never done before. For me HRT (hormone replacement therapy) was always out of the question, as I don’t like to interfere with my body in such a dramatic way. Plus you get all the side effects. So I tried with herbal remedies like sage and homeopathic drops – these things did help for a while but soon it was always back to square one. With HMD™ it was a different story. Nothing much happened at first but after a few weeks, I started seeing results. I started to sleep better and my mood improved. The hot flashes also started to get less and less. I have now been taking it for 4 months and I am amazed how it has transformed my life. I still have hot flashes occasionally but it’s bearable now. I have even noticed an improvement in my migraines - something that I have always suffered from. I would usually have an attack at least once a week – now I have not had one for the last 17 days. Somehow I feel that my whole life has become wholesome again and I am very thankful for this development. Despite the cost, HMD™ is definitely worth it!

Alex (USA): Doing beautifully! Autism
Alex is doing beautifully on the HMD™. I have been able to raise the dose. His speech is more frequent and clearer. His teacher reports "great" days at school. He is pretty regular and seems to actually be stimulated to move his bowels after his daily dose of HMD™ most times. There are other changes such as:singing with me, just knowing the words all of a sudden to songs, understanding us better, hearing better, etc.

Irina (UK): I can finally breathe again! Severe allergies, eczema
I have been taking HMD™ for 3 months now and the effects are absolutely amazing. 7 years ago I was diagnosed with Hodgkin lymphoma [cancer of the lymph nodes]. I was cured but have been suffering from severe allergies and skin problems ever since. I am (or have been) allergic to any kind of pollen as well as dust and for the past 6 years tissues and anti-histamines have been my constant companions. Every morning I would wake up to sneezing attack as well as itching eyes, throat and ears. My sinuses were constantly blocked and I could only ever breathe through my mouth, or one nostril at most. In addition my skin would randomly break out in eczema in different spots on my neck, back and arms. After reading about metal toxicity on the Internet I decided to try HMD™. Nothing much happened during the first 4 weeks and I was very discouraged. However during my second month I began to see rapid improvements. Suddenly I didn’t sneeze any more and my skin cleared up completely. I stopped taking anti-histamines and could finally leave the tissues at home. In my third month my sinuses started to clear up. And finally, after 6 long years, I can breathe properly through my nose again! In addition people have started complementing me on my skin, complexion and general energy level. It’s amazing. It may seem like a small thing, but it has made a huge change to my life and my overall well-being. I am glad I bought the full 90-day course – otherwise I may have given up after the first bottle. I will definitely continue taking this amazing producton a maintenance dose. Thank you HMD™!

Aaron, (US): An exhilarating experience! Acute skin problems
I would first of all like to say thank you for your research in regards to HMD™. I have purchased it, and I would like to give a bit of feedback so far. I have been taking HMD™ for about a week and a half, and here is what I have experienced so far. I am 32 years old and in pretty good health. However I have a condition of systemic candidiasis that I have had symptoms of for the last ten years, with toxic metals like mercury being one of the causative factors to this problem. With the Candida, my biggest problem was of a condition called pruritis, which is cuts or breaking of the skin that would be both painful, and extremely irritating and itchy. This itching and the pain from the eruptions or cuts in the skin would keep me up all night, and torture me throughout the day. I thought for sure after doing some research that I might have a lot of mercury built up and I was possibly allergic to mercury. The doctors called it dermatitis, eczema and psoriasis, and of course had no real answer for it. I also had these pink spots in that area which became worse (larger and more of them) in time, as well as some sort of scaly spots that would show up from time to time as well. I also just dealt with itching all over other parts of my body as well. When I started taking HMD™, those issues on the third day as well just went really bad. The cuts or eruptions started to manifest and it was pretty severe. I continued to take the HMD™, and as of today the cuts have healed, and the itching has lessened quite a bit. The spots are still there, and I realize that it takes time, but I am hopeful that this condition will disappear in time with using HMD™. October 2010 I just wanted to update some of the benefits I have received from using the HMD™ so far for quite a few months. So far the most amazing thing I have noticed is my increased cognitive function. I believe this HMD™ not only crosses the blood brain barrier, but actually pulls metals like mercury out. I did notice every once in a while a small dull headache that would subside after a few hours, as well as helping it with some extra magnesium. I got to admit, its an exhilarating experience with the increased brain power, as even with my studies regarding holistic medicine, its changed the 'game' so to speak. Its all falling into place, and just the way I seem to process the different forms of data coming into my brain is different. I already have a pretty good brain that God gave me, and with this rubbish being removed its just gotten better. I have also noticed a small difference with mental health and stability. I don't have any depression or any mental disorders, but I noticed a more calm feeling and a small improvement, just in mood in general. Due to losing my job I had to hold off on all the supplements needed to cure me of the Candida, but I have seen a marked improvement. The pruritis has minimized quite a bit, although its still happens on a small scale, especially if I don't keep away from sugars and simple carbs. Other irritations of my skin have gotten a lot better as well, as I am sure they are just another symptom of the systemic candida. I will be applying your protocol for removal and conversion of candida asap. Thank you!

Ana (USA): I love it - whole family benefits! Asperger’s, ADHD, Headaches
I love what the HMD™ has done for my son's mood and health. My son has a diagnosis of Asperger's and has responded wonderfully to the HMD™ product. I especially like that its chlorella and cilantro based because it's more gentle but still synergistically potent. Because he is extremely sensitive we started out very slowly and after 3 months are up to his suggested dose. I saw a difference within the first week in his hyperactive behavior and anxiety level. He is more calm, clear headed and aware of the environment around him and can engage in family discussions without being cued. He is better able to cope with daily frustrations and although he still becomes frustrated he can now listen to reason and negotiate as needed for more streamlined and natural communication. During the first week I took the supplement with him to get a sense of its effects and I found that I was better able to focus and less anxious. I was also able to complete more tasks and my ADHD symptoms were greatly minimized. My partner took it for the first week also and he found that his 'regular'headaches completely disappeared. I know that this is a product that is meant to work slowly and over time but we all saw huge gains very early on in many aspects of our functioning. Unfortunately since I'm on a fixed budget I can only afford to get this wonderful product for my son, but if I could afford it I would get it for my entire family. I also especially appreciate the newsletter and all the wonderful educational informationon the website. Although I have been researching health and detoxification issues for about 5 years I found the site extremely helpful. This is a wonderful product and I recommend it to anyone who will listen (because there are so many possibilities for toxicity in our current environment).

Anna (UK): Feeling much better and more alive! Amalgam Removal
I have been taking HMD™ now for 4 months consecutively at a dosage of 50 drops x 3 daily. I began taking it after having 6 amalgams removed with no detoxification programme to cover me - after a few months I felt really tired, dry skin, sore muscles and a general apathy towards life. A test showed that I had high levels of mercury as well as arsenic (I am a vegetarian so eat plenty of vegetables with pesticides as I cannot afford organic). I now feel so much better with the HMD™ - my energy has greatly improvedand the pain in my muscles has gone completely. I am also feeling so much better and more alive!

Roger (UK): Muscle Movements improved! MS
I was diagnosed with heavy metal toxicity some time ago after developing MS at the age of 45 years. I have led a toxic life as a welder and a part-time farmer, spraying the crops with lots of arsenic-laden sprays. I have been taking HMD™ for 6 months now - even though I am still not walking I can honestly say that my muscle movements are much better - I can actually wiggle my toes now, something that I could not do before. I am also generally feeling much more energized and my mind is working much better as I can concentrate for much longer periods of time.

Dianne (Spain): Very happy! Irregular periods, hay fever
I am 46 and until a month ago, having started a course of HMD™, had never had a normal menstrual period in my life! Until I went on the Pill, my periods had always been very erratic in frequency and lasting about 15 days! I would have an unpleasant brownish discharge for about 10 days pre-menstrually and then the normal flow would come for about 5 days. On coming off the Pill, in order to start a family, it became apparent that I was infertile and medical tests showed a hormonal abnormality, but no explanation could be found for this. On leaving off the Pill, my periods were more regular, but the discharge continued. I started taking HMD™ 2 months ago (Jan. 2007), corresponding with the beginning of a menstrual cycle, and at the end of that month, for the first time, there was no discharge at all prior to the period! At the end of the second month, there was just a tiny amount on the 2 days pre-menstrually, which I am very happy about. Other improvements I've noticed since starting HMD™ are that I no longer wake up in the mornings in a mental fog which would previously take a couple of hours to shake off, and in general I feel more alert and focused. My hair, which has always been thin and lifeless, looks healthier and more full-bodied. I intend to continue taking HMD™ having experienced this new lease of life, with the added bonus of knowing that my body is becoming less toxic by the day, and that I can expect to have a healthier life in the future. Update February 2008: I have now been taking HMD™ continuously for just over a year and am still enjoying the above benefits of a more healthy, energy-filled new life.I would just like to add that an added bonus has been that last summer, for the first time in 44 years, I had absolutely no symptoms of the severe hayfever (mainly an allergy to grass pollens) which had made my summers so unbearable. The endless sneezing and resultant raw nose were bad enough, but my itchy eyes, which in the end I couldn’t help but rub and thus make even more inflamed, resulted in two months of misery each year, as no pills or drops could relieve it. I’m sure this cure was due to HMD™ removing the toxic metals which were causing my system to react adversely to the pollens. I am very grateful for this. Thank you.

Autistic Child (USA): Great Results! Autism
We are having great results with HMD™. It's very cheap, gentle, and effective. I will be posting our son's hair/urine/fecal tests and mercury is showing on urine/fecal for the first time in four years. We are only about 1/4 through the first bottle. Also we are all of a sudden seeing URANIUM big time in my son's faecal test! My network of doctors/parents/etc. is also seeing a sudden rise in uranium in testing. I think you know what that means for us all ....

Tony (UK): Thank you for this wonderful product! Toxicity from Amalgams
I am enjoying the product and its ''gentleness''. Within 48 hours of taking the heavy metal detox product I experienced a better increase in concentration. Since taking the product since for well over a month now I have experienced a few improvements. 1. The coldness in my feet that I feel in the morning has now completely gone. 2. My mood and temperament have reached an even keel, something that I was truly grateful for. 3. I have now for many years had a rapid increase in heart rate an ''exploding" feelingwhen I am sleeping and since taking the product that has now completely disappeared. I also enjoy the quality of the chlorella tablets something that I have not experienced in other chlorella tablets. Thank you for this wonderful product.
UPDATE FROM TONY JANUARY 2011:
After taking the HMD™ now for near 2 months, I have noticed a few other improvements and enhancements in my health. 1. The tinnitus in my ear has abated somewhat I am sure that as I continue to take the product it will diminish further, as it gradually has been. 2. At times my neck has this ''swollen'' feeling but I have noticed taking the chlorella (dosage about 10 a day) tablets has eased the mild pain that I feel. I expect this to reduce in time as I continue with my projection of the HMD™ program. 3. I have also noticed that as a continuation, my general well being has improved further with time and my wider vision has also expanded. 4. That ''internal'' coldness that I have always felt is slowly working its way out of my system something that I noticed three weeks in the program.

Susan (USA): Encouraged and much better! Metal Allergies
I just received a call from a gal that I gave an HMD™ sample to a week ago. She was so highly toxic that even touching coins would cause a metal taste in her mouth. After 2 days she noticed she woke up - wide awake- as she says. This has never happened. She can now, after a week, pick up a metal fly swatter without feeling and tasting metal in her teeth as drastically as she had before. She still got a small charge in her mouth. She is on a very low dose - 20 drops twice a day. She was so afraid to start anything more “heavy” as her reaction could be dire. She worked in the plumbing industry for years and handled metals, thus her build-up. She is feeling encouraged and feeling much better.

Jane (Cyprus): Remarkable improvements! Low energy levels with short-term memory loss
As a new user of HMD™ (two & a half weeks) the measurable health improvements have been remarkable. Within a couple of days of commencing with HMD™ I first noticed how much healthier I felt. Most significant was the tangible increase of my energy levels. To achieve this normally involved consuming numerous cups of tea & coffee to kickstart my system, whereas now they are not required. I am now more alert & dynamic throughout the day. In addition, my short term memory is also showing signs of improvement. I have no doubt these changes are attributable to the HMD™ product and I will be purchasing a second bottle in the near future.

H (UK):It’s a miracle! Mercury Poisoning through amalgam fillingsI obtained your details from the web and am interested in your HMD™ formulation using a homaccord of Chlorella, CGF and Cilantro as I wish to self-medicate myself, since I feel sure that I am suffering from the effects of mercury poisoning through amalgam fillings administered to me since at least the 1940's, I am over 77 years of age. I have noticed the symptoms since last autumn and I am sure it is affecting my work as a writer.It’s a miracle, no less - let me tell you. I ordered the product on Monday, received it Wednesday, took it Thursday, and twice today, Friday so far. I walked to the shops this morning and felt marvelous. I have just got in from a six mile walk, mainly on the beach, and have felt in near peak condition, like I haven’t felt for years. The pain in the knees had gone, I could run a bit, I never staggered with shortness of breath, and never collapsed on the settee after returning and falling asleep.The ringing headaches that I feared the most have gone so far today. I feel like a new man already, and capable of achieving my writing work that I have been so sluggish and inconsistent with this Autumn and Winter. I am amazed; it just MUST BE your miracle formula HMD™. I will continue taking this for two months but I am amazed as I am, as suggested, only on 25 drops, three times daily. In short I offer you my complete gratitude for inventing and marketing your product. Thank you from the bottom of my heart, certainly nothing else has or could achieve these results.

Laurie (Kuwait): Tremors, panic attacks, insomnia Sensation of having a heart attack

I am truly thankful for HMD™. I truly have to say that HMD™ has been a huge blessing in my life - a real God-send without question.  My battle with strange “symptoms” began at the end of June in 2009.  For several months  I struggled with a wide range of feelings/sensations - continual “symptoms” that were beyond annoying, to the point of distressing.   Just to name a few, these included tremors (internal and external),  sensations of having a heart attack or stroke, panic attacks, insomnia, sensitivity to sound/light/smell; pulling in jaw, twitching,--and the list could go on. Numerous medical tests were run.  No sure diagnosis was given.

Believing my problems could possibly be related to heavy metals, I began to take HMD™ (Tripack) on January 3, 2010.  Little by little, slowly but surely, I have been watching myself progress back to normalcy.  It seems that HMD™ has gently, safely, and naturally been bringing me through to recovery.  I am so thankful to God for this wonderful product.

Dr. Hisham (Egypt): Great Results! I'd like to let you know about one of my patients here in Egypt: Lead toxicity, paralysis, blindness, depression, vomiting - 28-year old woman:The patient is now a 28-year old university graduate whose problem began 7 years ago with neck pains that progressed to semi-paralysis of the hands and feet. She began taking certain vitamins and minerals in high dosages, which helped initially, but she was left with a limp.About 2 years ago the same symptoms appeared again but the progressive degeneration was much faster this time. Her vision was affected with blurring and white shadows until she became completely blind. She also became chronically depressed.During this time she saw many doctors of different specialties such as internal medicine specialists, neurologists, psychiatrists and others. She had developed a loss of sensation in her feet, with excruciating pain in her whole body, to the point where anyone touching her caused excruciating pain – there was no way that she could be seated upright by herself. Her blood pressure had reached 200/100 and she was started on anti-hypertensive drugs to control this. Her pulse rate increased and she began vomiting, with little appetite.She also had peeling of the skin of her feet which was quite marked.During the last 5 months her symptoms got worse with oedema of the legs and clonus of the feet. She began biting her tongue and cortisone therapy was begun to control the swelling. There were also chronic, unbearable abdominal cramps. Even her facial features had changed due to bone protrusion in her face. She had a very bad taste in her mouth with a metallic characteristic. Her voice was very erratic and it was difficult to understand what she was saying. She could not sleep for longer than a couple of hours at a time.Interestingly, at the back of the skull on the occipital region there was a distinct softening of the cranial bone with a puss-like viscous fluid extruding from the skull, making the hair all sticky.Diagnostic testing using EMG showed chronic axonal polyneuropathy. MRI showed abnormal signal intensity in the white matter of the occipital and posterior parietal lobes on both sides consistent with white matter disease or dural matter disease. ESR was elevated at 70, RBC count was low at 3.81 and she was very anaemic looking, her HGB was low at 9.8, HCT low at 26, MCV low at 70.1, S; was creatinine low at 0.3 and albumin low at 2.1. A Tissue Hair Mineral Analysis was performed as an initial screening test to determine the levels of toxic metals – lead was found to be 1,000% higher than the reference range. About 2 months ago this lady began taking HMD™ (Heavy Metal Detox) once the hair analysis showed high toxic metals, particularly lead. Within a short period of time she began seeing dramatic improvements such as: * The sensitivity of the skin and pain in the bones had gone completely and it was possible to touch her again * The stiffness in the knee had gone * The abdominal cramps had gone completely * Her facial features had changed as the bones in her face that had a protrusions returned back to their initial position * Vision has improved somewhat and she is now able to see shadows * The oedema in the ankles has now gone and she can now sit unaided, something that was very difficult before * Her voice has now returned to normal – before it was very erratic and communication was difficult * She can now sleep for long hours and get the rest that she requires * Her left arm that was completely paralyzed and had swelled considerably, has now gone and she can move her arm much better. On the 29.07.07 this lady was seen by the inventor of HMD™, Dr. Georgiou, at the Da Vinci Clinic Egypt on one of his trips there and confirmed the diagnosis of lead poisoning with ART resonance testing showing lead accumulations in the occipital cortex, the liver and kidneys. A more detailed and complex detoxification regime was begun for this lady, using HMD™ as one of the main chelators, along with drainage remedies and high mineral levels. Her progress will be carefully monitored and reported here for the benefit of all.

Kenny (Vancouver Island, Canada): People need to know this stuff really works!
Thank you so much for creating this wonderful product. I've had horrible health problems for years, insomnia being the worst one. I started having a burning feeling in my brain and finally traced all my life's problems to the mercury in my silver fillings. I tried nearly everything under the sun for insomnia and nothing seemed to help. I tried melatonin, 5-HTP, herbs, ect. I even tried medical marijuana which helped a small percent. The HMD™ was really working the third day I was on it at the full dosage at 45 drops x 3 times a day. I'm not sure if it really was or maybe this was all in my head? My mind might have been at rest knowing I'm on the road to recovery with HMD™. Day 15 rolls along and my insomnia is 50% improved. By the time I've finished 2 bottles my insomnia has vanished. I had no idea the HMD™ would work this good considering my 9 amalgam silver fillings are still in my mouth. Three of them are cracked wide open. I feel like the HMD™ is protecting me from anymore mercury damage. I am getting the fillings out in a few weeks. I have been taking the LAVAGE and CHLORELLA too which are amazing. Chlorella is the worlds healthiest food aside from spirulina. Not sure why people think chemical chelation is the right way to detox. Why pour more chemicals in your body when your already toxic? Our bodies are self detoxing if we eat the right healthy foods. Cilantro and chlorella are those foods. I have one more bottle of HMD™ that I'm on right now from the detox pack. That's okay because my new HMD™ order should be here any day including my iodine. I heard 90% of the world is deficient in iodine. I wonder if this is true? Please get your fillings out the safe way by a mercury-free dentist. Take HMD™ and protect yourself. Thanks again. PS: I would love for you to put me on the site. People need to know this stuff really works! My cold hands are about 70% gone. Stomach pains are 100% gone. I've only taken two bottles. If it works this good I wonder how good I will feel after a year on HMD™. Amazing!

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Content Analysis	Bad SEO scoreYou have not used your focus keyword in any subheading (such as an H2) in your copy. Bad SEO scoreThe keyword density is 0%, which is a bit low; the focus keyword was found 2 times. OK SEO scoreNo outbound links appear in this page. Consider adding some as appropriate. OK SEO scoreThe meta description is under 120 characters, however up to 156 characters are available. OK SEO scoreThe page title contains 27 characters, which is less than the recommended minimum of 40 characters. Use the space to add keyword variations or create compelling call-to-action copy. Good SEO scoreThe copy scores 66.6 in the Flesch Reading Ease test, which is considered ok to read. Good SEO scoreThe text contains 6888 words, this is more than the 300 word recommended minimum. Good SEO scoreThe images on this page contain alt attributes with the focus keyword. Good SEO scoreThe focus keyword appears in the URL for this page. Good SEO scoreThe meta description contains the focus keyword. Good SEO scoreThe page title contains the focus keyword, at the beginning which is considered to improve rankings. Good SEO scoreThe focus keyword appears in the first paragraph of the copy. Good SEO scoreYou've never used this focus keyword before, very good.

Uranium detox,

URANIUM DETOX Cynthia USA - Our family apparently was exposed to uranium because it appeared in hair analysis and urine tests. We discovered we lived in an area where there were veins of uranium running underground through the town and later read in news accounts that the EPA was testing wells for uranium in our area. As soon as we learned that we apparently had been exposed, we tried HMD. It was a relief to know that there were options for detoxification, especially for our children, that wouldn’t be harmful. Later testing showed that the levels had reduced by half in about 6 months. I have recommended HMD to friends with autistic children.

TOXIC METALS AND SLEEP,

TOXIC METALS AND SLEEP Susanne (Spain) - I just want to say that the HMD detox is working very very good with me…After the first week I had kind of flu symptoms but after that I began feeling better. I also had pain flashes in some of my teeth but that has gone too now and I am feeling overall better. My hair has started growing again, skin and my eyes look clearer and more healthy as well. I havent slept as well for years as I do now after 10 days on the metal detox. It is really a good product and the best money I have spent in a long time.

WORLDWIDE: (+357) 24 82 33 22

Author Archive for: George Detox

About George Detox

Kelly E (MN, USA): ‘I just wanted to say THANK YOU! I know your products WORK!’ Chronic fatigue

Adrian (Spain): ‘I am feeling better with every decrease in mercury’ Severe depression and anxiety

Kayla, (US): “This detox has healed my body.” Interstitial cystitis & Lifelong cystic acne

Susanne (Spain): Really a good product and the best money I have spent in a long time. GENERAL ILL HEALTH DUE TO AMALGAM FILLINGS

Michelle (Sacramento, USA): Amazing progress! Mitochondrial dysfunction

Cynthia (USA): Uranium levels reduced by half! Uranium exposure

Ingrid (UK): Expensive but worth it! Severe Menopause, insomnia, migraine

Alex (USA): Doing beautifully! Autism

Irina (UK): I can finally breathe again! Severe allergies, eczema

Aaron, (US): An exhilarating experience! Acute skin problems

Ana (USA): I love it - whole family benefits! Asperger’s, ADHD, Headaches

Anna (UK): Feeling much better and more alive! Amalgam Removal

Roger (UK): Muscle Movements improved! MS

Dianne (Spain): Very happy! Irregular periods, hay fever

Autistic Child (USA): Great Results! Autism

Tony (UK): Thank you for this wonderful product! Toxicity from Amalgams

UPDATE FROM TONY JANUARY 2011:

Susan (USA): Encouraged and much better! Metal Allergies

Jane (Cyprus): Remarkable improvements! Low energy levels with short-term memory loss

Laurie (Kuwait): Tremors, panic attacks, insomnia Sensation of having a heart attack

Kenny (Vancouver Island, Canada): People need to know this stuff really works!

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WISHING YOU ALL A JOYOUS AND HEALTHY

CHRISTMAS AND NEW YEAR!